2-(4'-(a-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)acetic acid

Base Information

Chemical Name:2-(4'-(a-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)acetic acid
CAS No.:1338326-82-1
Molecular Formula:C₂₁H₁₇ClN₄O₄
Molecular Weight:424.843
Hs Code.:

Synonyms:2-(4'-(a-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)acetic acid

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Chemical Property of 2-(4'-(a-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)acetic acid

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Technology Process of 2-(4'-(a-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)acetic acid

There total 11 articles about 2-(4'-(a-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1338326-83-2
methyl 2-(40-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)acetate

: 1338326-82-1
2-(4'-(a-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)acetic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; water; at 50 ℃; for 0.75h; Inert atmosphere;
DOI:10.1039/c2md20231j

Reference yield:

: 1259022-53-1
methyl 2-(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

: 1338326-82-1
2-(4'-(a-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water; methanol / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation; Sealed tube

2.1: water; lithium hydroxide / 1,4-dioxane / 0.75 h / 45 °C / Inert atmosphere

2.2: pH ~ 3 - ~ 4

With potassium phosphate; water; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; 1.1: Suzuki Coupling;

Reference yield:

: 1338326-85-4
6-(4-bromophenyl)-4-chloro-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

: 1338326-82-1
2-(4'-(a-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / 1,4-dioxane / 20 - 45 °C

2.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water; methanol / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3.1: water; lithium hydroxide / 1,4-dioxane / 0.75 h / 45 °C / Inert atmosphere

3.2: pH ~ 3 - ~ 4

With potassium phosphate; ammonia; water; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; 2.1: Suzuki Coupling;