(R)-4-amino-6-(2'-chloro-4'-(2-(3-hydroxypyrrolidin-1-yl)-2-oxoethyl)biphenyl-4-yl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Base Information

Chemical Name:(R)-4-amino-6-(2'-chloro-4'-(2-(3-hydroxypyrrolidin-1-yl)-2-oxoethyl)biphenyl-4-yl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one
CAS No.:1338326-25-2
Molecular Formula:C₂₅H₂₄ClN₅O₄
Molecular Weight:493.95
Hs Code.:

Synonyms:(R)-4-amino-6-(2'-chloro-4'-(2-(3-hydroxypyrrolidin-1-yl)-2-oxoethyl)biphenyl-4-yl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

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Chemical Property of (R)-4-amino-6-(2'-chloro-4'-(2-(3-hydroxypyrrolidin-1-yl)-2-oxoethyl)biphenyl-4-yl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

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Technology Process of (R)-4-amino-6-(2'-chloro-4'-(2-(3-hydroxypyrrolidin-1-yl)-2-oxoethyl)biphenyl-4-yl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

There total 11 articles about (R)-4-amino-6-(2'-chloro-4'-(2-(3-hydroxypyrrolidin-1-yl)-2-oxoethyl)biphenyl-4-yl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.9%

: 1338326-82-1
2-(4'-(a-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)acetic acid

: 104706-47-0,111810-68-5
(R)-3-hydroxypyrrolidine hydrochloride

: 1338326-25-2
(R)-4-amino-6-(2'-chloro-4'-(2-(3-hydroxypyrrolidin-1-yl)-2-oxoethyl)biphenyl-4-yl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 2h; Inert atmosphere;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1338326-25-2
(R)-4-amino-6-(2'-chloro-4'-(2-(3-hydroxypyrrolidin-1-yl)-2-oxoethyl)biphenyl-4-yl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 72 h / 60 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 2.02 h / 0 °C / Inert atmosphere

3.1: hydrogenchloride / methanol / 0.5 h / 18 - 25 °C / Inert atmosphere

4.1: triethylamine / acetonitrile / 6 h / 80 °C / Inert atmosphere

5.1: ammonia / 1,4-dioxane / 20 - 45 °C

6.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water; methanol / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation; Sealed tube

7.1: water; lithium hydroxide / 1,4-dioxane / 0.75 h / 45 °C / Inert atmosphere

7.2: pH ~ 3 - ~ 4

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 18 - 25 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; ammonia; water; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile; 6.1: Suzuki Coupling;

Reference yield:

: 87600-97-3
4,6-dichloropyrimidine-5-carboxylic acid chloride

: 1338326-25-2
(R)-4-amino-6-(2'-chloro-4'-(2-(3-hydroxypyrrolidin-1-yl)-2-oxoethyl)biphenyl-4-yl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran / 2.02 h / 0 °C / Inert atmosphere

2.1: hydrogenchloride / methanol / 0.5 h / 18 - 25 °C / Inert atmosphere

3.1: triethylamine / acetonitrile / 6 h / 80 °C / Inert atmosphere

4.1: ammonia / 1,4-dioxane / 20 - 45 °C

5.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water; methanol / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation; Sealed tube

6.1: water; lithium hydroxide / 1,4-dioxane / 0.75 h / 45 °C / Inert atmosphere

6.2: pH ~ 3 - ~ 4

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 18 - 25 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; ammonia; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile; 5.1: Suzuki Coupling;