(2S,2'R,5'S)-5'-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-5-[(3S,4S,5R,Z)-6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3,5-dimethylhex-1-enyl]-2,5'-dimethyloctahydro-2,2'-bifuran

Base Information

• Chemical Name: (2S,2'R,5'S)-5'-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-5-[(3S,4S,5R,Z)-6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3,5-dimethylhex-1-enyl]-2,5'-dimethyloctahydro-2,2'-bifuran
• CAS No.: 1184871-34-8
• Molecular Formula: C₅₀H₇₆O₆Si₂
• Molecular Weight: 829.321
• Mol file: 1184871-34-8.mol

Synonyms:(2S,2'R,5'S)-5'-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-5-[(3S,4S,5R,Z)-6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3,5-dimethylhex-1-enyl]-2,5'-dimethyloctahydro-2,2'-bifuran

Chemical Property of (2S,2'R,5'S)-5'-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-5-[(3S,4S,5R,Z)-6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3,5-dimethylhex-1-enyl]-2,5'-dimethyloctahydro-2,2'-bifuran

Chemical Property:

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Technology Process of (2S,2'R,5'S)-5'-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-5-[(3S,4S,5R,Z)-6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3,5-dimethylhex-1-enyl]-2,5'-dimethyloctahydro-2,2'-bifuran

There total 1 articles about (2S,2'R,5'S)-5'-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-5-[(3S,4S,5R,Z)-6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3,5-dimethylhex-1-enyl]-2,5'-dimethyloctahydro-2,2'-bifuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-{[(2S,2'R,5S,5'S)-5'-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl]methylsulfonyl}-1-phenyl-1H-tetrazole + (2R,3R,4R)-5-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-2,4-dimethylpentanal (235785-57-6) → (2R,3S,4S)-6-((2S,2'R,5S,5'S)-5'-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-2,5'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-1-((tert-butyldiphenylsilyl)oxy)-2,4-dimethylhex-5-en-3-ol (1184871-25-7) + (2S,2'R,5'S)-5'-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-5-[(3S,4S,5R,Z)-6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3,5-dimethylhex-1-enyl]-2,5'-dimethyloctahydro-2,2'-bifuran (1184871-34-8)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at -78 - 0 ℃; optical yield given as %de; Inert atmosphere;

DOI:10.1002/anie.200901608

upstream raw materials:

(2R,3R,4R)-5-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-2,4-dimethylpentanal