4-[(1R,3R,4R)-3-(4-bromophenyl)-4-{[(1S)-1-(4-chlorophenyl)ethyl]-carbamoyl}cyclohexyl]morpholine

Base Information

Chemical Name:4-[(1R,3R,4R)-3-(4-bromophenyl)-4-{[(1S)-1-(4-chlorophenyl)ethyl]-carbamoyl}cyclohexyl]morpholine
CAS No.:1350710-85-8
Molecular Formula:C₂₅H₃₀BrClN₂O₂
Molecular Weight:505.882
Hs Code.:

Synonyms:4-[(1R,3R,4R)-3-(4-bromophenyl)-4-{[(1S)-1-(4-chlorophenyl)ethyl]-carbamoyl}cyclohexyl]morpholine

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Chemical Property of 4-[(1R,3R,4R)-3-(4-bromophenyl)-4-{[(1S)-1-(4-chlorophenyl)ethyl]-carbamoyl}cyclohexyl]morpholine

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Technology Process of 4-[(1R,3R,4R)-3-(4-bromophenyl)-4-{[(1S)-1-(4-chlorophenyl)ethyl]-carbamoyl}cyclohexyl]morpholine

There total 3 articles about 4-[(1R,3R,4R)-3-(4-bromophenyl)-4-{[(1S)-1-(4-chlorophenyl)ethyl]-carbamoyl}cyclohexyl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350711-82-8
(1R,2R,4R)-2-(4-bromophenyl)-4-morpholin-4-ylcyclohexanecarboxylic acid hydrochloride

: 4187-56-8
(S)-1-(p-chlorophenyl)ethylamine

: 1350710-85-8
4-[(1R,3R,4R)-3-(4-bromophenyl)-4-{[(1S)-1-(4-chlorophenyl)ethyl]-carbamoyl}cyclohexyl]morpholine

Guidance literature:: With 2-( 1H-7-azabenzotniazol-1-yl)-1,1,3,3-tetrarmethyluroniumhexafluorophosphate methanaminium; N-ethyl-N,N-diisopropylamine; In dimethyl amine; at 20 ℃;
DOI:10.1016/j.bmcl.2013.09.094

Reference yield:

: C₁₈H₂₄BrNO₃

: 1350710-85-8
4-[(1R,3R,4R)-3-(4-bromophenyl)-4-{[(1S)-1-(4-chlorophenyl)ethyl]-carbamoyl}cyclohexyl]morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / 24 h / 70 °C

2: 2-( 1H-7-azabenzotniazol-1-yl)-1,1,3,3-tetrarmethyluroniumhexafluorophosphate methanaminium; N-ethyl-N,N-diisopropylamine / dimethyl amine / 20 °C

With 2-( 1H-7-azabenzotniazol-1-yl)-1,1,3,3-tetrarmethyluroniumhexafluorophosphate methanaminium; water; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In dimethyl amine;
DOI:10.1016/j.bmcl.2013.09.094

Reference yield:

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 1350710-85-8
4-[(1R,3R,4R)-3-(4-bromophenyl)-4-{[(1S)-1-(4-chlorophenyl)ethyl]-carbamoyl}cyclohexyl]morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran

2: 2-( 1H-7-azabenzotniazol-1-yl)-1,1,3,3-tetrarmethyluroniumhexafluorophosphate methanaminium; N-ethyl-N,N-diisopropylamine / dimethyl amine / 20 °C

With 2-( 1H-7-azabenzotniazol-1-yl)-1,1,3,3-tetrarmethyluroniumhexafluorophosphate methanaminium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl amine;
DOI:10.1016/j.bmcl.2013.09.094