Technology Process of (1R,2R,4R)-2-(4-bromophenyl)-4-morpholin-4-ylcyclohexanecarboxylic acid hydrochloride
There total 9 articles about (1R,2R,4R)-2-(4-bromophenyl)-4-morpholin-4-ylcyclohexanecarboxylic acid hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl (1R,2R,4R)-2-(4-bromophenyl)-4-morpholin-4-ylcyclohexanecarboxylate;
With
lithium hydroxide;
In
tetrahydrofuran;
at 70 ℃;
for 24h;
With
hydrogenchloride;
In
water; acetone;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 0.58 h / -65 °C
2.2: 0.75 h / -65 °C
3.1: diethylaluminium chloride / dichloromethane / 0 - 20 °C
4.1: 2,2-Dimethyl-1,3-propanediol / toluene-4-sulfonic acid / toluene / 3 h / Reflux
4.2: 0 - 20 °C
5.1: sodium hydrogen sulfate / water; ethyl acetate / 12 h / 20 °C
6.1: methanol / benzene / 20 °C
7.1: titanium(IV) isopropylate / dichloromethane / 20 °C
7.2: -78 - 20 °C
8.1: lithium hydroxide / tetrahydrofuran / 24 h / 70 °C
8.2: Cooling with ice
With
titanium(IV) isopropylate; methanol; sodium hydrogen sulfate; n-butyllithium; oxalyl dichloride; diethylaluminium chloride; 2,2-Dimethyl-1,3-propanediol; lithium hydroxide;
toluene-4-sulfonic acid; N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 2,2-Dimethyl-1,3-propanediol / toluene-4-sulfonic acid / toluene / 3 h / Reflux
1.2: 0 - 20 °C
2.1: sodium hydrogen sulfate / water; ethyl acetate / 12 h / 20 °C
3.1: methanol / benzene / 20 °C
4.1: titanium(IV) isopropylate / dichloromethane / 20 °C
4.2: -78 - 20 °C
5.1: lithium hydroxide / tetrahydrofuran / 24 h / 70 °C
5.2: Cooling with ice
With
titanium(IV) isopropylate; methanol; sodium hydrogen sulfate; 2,2-Dimethyl-1,3-propanediol; lithium hydroxide;
toluene-4-sulfonic acid;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene; benzene;
