3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide

Base Information

Chemical Name:3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide
CAS No.:1414360-80-7
Molecular Formula:C₂₅H₃₃FN₄O₃S
Molecular Weight:488.626
Hs Code.:

Synonyms:3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide

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Chemical Property of 3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide

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Technology Process of 3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide

There total 6 articles about 3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1414360-79-4
3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]prop-2-enamide

: 1414360-80-7
3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 12h; under 3375.34 Torr;

Reference yield:

: 1179336-71-0
tert-butyl 4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

: 1414360-80-7
3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; isopropyl alcohol / tert-butyl methyl ether; 2-methyltetrahydrofuran / 28 h / 20 - 40 °C / Industry scale

2.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichlorobis(tri-O-tolylphosphine)palladium / acetonitrile / 16 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 3375.34 Torr

With hydrogenchloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; dichlorobis(tri-O-tolylphosphine)palladium; palladium 10% on activated carbon; In 2-methyltetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; acetonitrile; 3.1: Heck Reaction;

Reference yield:

: tert-butyl 7-oxa-3,10-diazaspiro[5.5]undecane-3-carboxylate hydrochloride

: 1414360-80-7
3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran; 2-methyltetrahydrofuran / 1 h / 5 - 20 °C / Industry scale

2.1: hydrogenchloride; isopropyl alcohol / tert-butyl methyl ether; 2-methyltetrahydrofuran / 28 h / 20 - 40 °C / Industry scale

3.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.2: 18 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichlorobis(tri-O-tolylphosphine)palladium / acetonitrile / 16 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 3375.34 Torr

With hydrogenchloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; dichlorobis(tri-O-tolylphosphine)palladium; palladium 10% on activated carbon; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; acetonitrile; 4.1: Heck Reaction;