3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]prop-2-enamide

Base Information

Chemical Name:3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]prop-2-enamide
CAS No.:1414360-79-4
Molecular Formula:C₂₅H₃₁FN₄O₃S
Molecular Weight:486.611
Hs Code.:

Synonyms:3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]prop-2-enamide

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Chemical Property of 3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]prop-2-enamide

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Technology Process of 3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]prop-2-enamide

There total 4 articles about 3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 7-oxa-3,10-diazaspiro[5.5]undecane-3-carboxylate hydrochloride

: 1414360-79-4
3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]prop-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran; 2-methyltetrahydrofuran / 1 h / 5 - 20 °C / Industry scale

2.1: hydrogenchloride; isopropyl alcohol / tert-butyl methyl ether; 2-methyltetrahydrofuran / 28 h / 20 - 40 °C / Industry scale

3.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.2: 18 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichlorobis(tri-O-tolylphosphine)palladium / acetonitrile / 16 h / Reflux

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; dichlorobis(tri-O-tolylphosphine)palladium; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; tert-butyl methyl ether; acetonitrile; 4.1: Heck Reaction;

Reference yield:

: (2-isopropylthiazol-4-yl)-(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone dihydrochloride

: 1414360-79-4
3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]prop-2-enamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichlorobis(tri-O-tolylphosphine)palladium / acetonitrile / 16 h / Reflux

With triethylamine; N-ethyl-N,N-diisopropylamine; dichlorobis(tri-O-tolylphosphine)palladium; In dichloromethane; acetonitrile; 2.1: Heck Reaction;

Reference yield:

: 234445-61-5
2-isopropyl-1,3-thiazol-4-carboxylic acid

: 1414360-79-4
3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]prop-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran; 2-methyltetrahydrofuran / 1 h / 5 - 20 °C / Industry scale

2.1: hydrogenchloride; isopropyl alcohol / tert-butyl methyl ether; 2-methyltetrahydrofuran / 28 h / 20 - 40 °C / Industry scale

3.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.2: 18 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichlorobis(tri-O-tolylphosphine)palladium / acetonitrile / 16 h / Reflux

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; dichlorobis(tri-O-tolylphosphine)palladium; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; tert-butyl methyl ether; acetonitrile; 4.1: Heck Reaction;