(3R,5R)-7-(tert-butyldiphenylsilyloxy)-5-(triethylsilyloxy)-3-(triisopropylsilyloxy)hept-1-yne

Base Information

Chemical Name:(3R,5R)-7-(tert-butyldiphenylsilyloxy)-5-(triethylsilyloxy)-3-(triisopropylsilyloxy)hept-1-yne
CAS No.:850588-48-6
Molecular Formula:C₃₈H₆₄O₃Si₃
Molecular Weight:653.181
Hs Code.:

Synonyms:(3R,5R)-7-(tert-butyldiphenylsilyloxy)-5-(triethylsilyloxy)-3-(triisopropylsilyloxy)hept-1-yne

Suppliers and Price of (3R,5R)-7-(tert-butyldiphenylsilyloxy)-5-(triethylsilyloxy)-3-(triisopropylsilyloxy)hept-1-yne

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Chemical Property of (3R,5R)-7-(tert-butyldiphenylsilyloxy)-5-(triethylsilyloxy)-3-(triisopropylsilyloxy)hept-1-yne

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Technology Process of (3R,5R)-7-(tert-butyldiphenylsilyloxy)-5-(triethylsilyloxy)-3-(triisopropylsilyloxy)hept-1-yne

There total 6 articles about (3R,5R)-7-(tert-butyldiphenylsilyloxy)-5-(triethylsilyloxy)-3-(triisopropylsilyloxy)hept-1-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 850588-47-5
(3R,5R)-7-(tert-butyldiphenylsilyloxy)-5-(triethylsilyloxy)hept-1-yn-3-ol

: 13154-24-0
triisopropylsilyl chloride

: 850588-48-6
(3R,5R)-7-(tert-butyldiphenylsilyloxy)-5-(triethylsilyloxy)-3-(triisopropylsilyloxy)hept-1-yne

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 22h;
DOI:10.1039/b417429a

Reference yield:

: 850588-45-3
(3R,5R)-7-(tert-butyldiphenylsilyloxy)-5-(triethylsilyloxy)-1-(trimethylsilyl)hept-1-yn-3-ol

: 850588-48-6
(3R,5R)-7-(tert-butyldiphenylsilyloxy)-5-(triethylsilyloxy)-3-(triisopropylsilyloxy)hept-1-yne

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / aq. K₂CO₃ / methanol / 10.5 h / 0 °C

2: 84 percent / imidazole / dimethylformamide / 22 h / 20 °C

With 1H-imidazole; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/b417429a

Reference yield:

: 994-30-9
triethylsilyl chloride

: 850588-48-6
(3R,5R)-7-(tert-butyldiphenylsilyloxy)-5-(triethylsilyloxy)-3-(triisopropylsilyloxy)hept-1-yne

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / imidazole / dimethylformamide / 20 °C

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: 84 percent / Me₂S / CH₂Cl₂ / 20 °C

3.1: n-BuLi / hexane; tetrahydrofuran / 1 h / -78 °C

3.2: 52 percent / hexane; tetrahydrofuran / 0.33 h / -78 °C

4.1: 91 percent / aq. K₂CO₃ / methanol / 10.5 h / 0 °C

5.1: 84 percent / imidazole / dimethylformamide / 22 h / 20 °C

With 1H-imidazole; n-butyllithium; potassium carbonate; ozone; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b417429a