6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine-3-carbohydrazide

Base Information

• Chemical Name: 6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine-3-carbohydrazide
• CAS No.: 1057314-57-4
• Molecular Formula: C₁₇H₁₈F₃N₅O₂
• Molecular Weight: 381.357
• Mol file: 1057314-57-4.mol

Synonyms:6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine-3-carbohydrazide

Chemical Property of 6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine-3-carbohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine-3-carbohydrazide

There total 2 articles about 6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid methyl ester (840488-99-5) → 6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine-3-carbohydrazide (1057314-57-4)

Guidance literature:

With hydrazine; In methanol; at 85 ℃; for 2.5h;

Reference yield:

methyl 6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine-3-carboxylate → 6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine-3-carbohydrazide (1057314-57-4)

Guidance literature:

With hydrazine hydrate; In methanol; for 2h; Reflux;

DOI:10.1016/j.bmcl.2009.11.111

Reference yield:

6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine-3-carbohydrazide (1057314-57-4) + acetyl chloride (75-36-5) → N'-acetyl-6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine-3-carbohydrazide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

upstream raw materials:

6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid methyl ester

Downstream raw materials:

N'-(2,2-dimethylpropanoyl)-6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine-3-carbohydrazide