8-(benzoylamino)octanoic acid

Base Information

• Chemical Name: 8-(benzoylamino)octanoic acid
• CAS No.: 43218-50-4
• Molecular Formula: C15H21NO3
• Molecular Weight: 263.3321
• Mol file: 43218-50-4.mol

Synonyms:

Chemical Property of 8-(benzoylamino)octanoic acid

Chemical Property:

• Vapor Pressure: 6.96E-11mmHg at 25°C
• Boiling Point: 501.6°C at 760 mmHg
• Flash Point: 257.2°C
• Density: 1.097g/cm³

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-(benzoylamino)octanoic acid

There total 4 articles about 8-(benzoylamino)octanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

8-Aminooctanoic acid (1002-57-9) + benzoic acid (65-85-0,8013-63-6) → N-benzoyl-8-aminooctanoic acid (43218-50-4)

Guidance literature:

benzoic acid; With pyridine; pentafluorophenyl trifloroacetate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

8-Aminooctanoic acid; With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1002/cbdv.201200076

Reference yield:

8-Aminooctanoic acid (1002-57-9) + benzoyl chloride (98-88-4) → N-benzoyl-8-aminooctanoic acid (43218-50-4)

Guidance literature:

Reference yield:

C18H29NO3Si → N-benzoyl-8-aminooctanoic acid (43218-50-4)

Guidance literature:

With sodium carbonate;

DOI:10.1021/jm990416r

upstream raw materials:

8-Aminooctanoic acid

benzoyl chloride

benzoic acid

Downstream raw materials:

2-Benzyloxycarbonyl-1(benzyloxycarbonylmethyl)ethyl 3-O-(8-Benzoylaminooctanoyl)-2-deoxy-2-tetradecanoylamino-α-D-glucopyranoside

N-[8-(hydroxyamino)-8-oxooctyl]benzamid

Refernces

• 1、 Leone-Bay,Freeman,O'Toole,Rosario-Gray,Salo-Kostmayer,Tai,Mercogliano,Baughman. "Studies directed at the use of a parallel synthesis matrix to increase throughput in an in vivo assay". . p. 3573 - 3576. Retrieved 2007/10/03.
• 2、 Leone-Bay, Andrea,Paton, Duncan R.,Freeman, John,Lercara, Christine,O'Toole, Doris,Gschneidner, David,Wang, Eric,Harris, Elizabeth,Rosado, Connie,Rivera, Theresa,DeVincent, Aldonna,Tai, Monica,Mercogliano, Frank,Agarwal, Rajesh,Leipold, Harry,Baughman, Robert A.. "Synthesis and evaluation of compounds that facilitate the gastrointestinal absorption of heparin". . p. 1163 - 1171. Retrieved 2007/10/03.