2-(3-methoxyphenyl)-3-(1,5-dithiahexyl)-but-3-enyl-2-cyanide

Base Information

• Chemical Name: 2-(3-methoxyphenyl)-3-(1,5-dithiahexyl)-but-3-enyl-2-cyanide
• CAS No.: 157834-98-5
• Molecular Formula: C₁₆H₂₁NOS₂
• Molecular Weight: 307.481
• Mol file: 157834-98-5.mol

Synonyms:2-(3-methoxyphenyl)-3-(1,5-dithiahexyl)-but-3-enyl-2-cyanide

Chemical Property of 2-(3-methoxyphenyl)-3-(1,5-dithiahexyl)-but-3-enyl-2-cyanide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-methoxyphenyl)-3-(1,5-dithiahexyl)-but-3-enyl-2-cyanide

There total 1 articles about 2-(3-methoxyphenyl)-3-(1,5-dithiahexyl)-but-3-enyl-2-cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-methoxyphenyl)-2-(2-methyldithian-2-yl)acetonitrile + methyl iodide (74-88-4) → 2-(3-methoxyphenyl)-3-(1,5-dithiahexyl)-but-3-enyl-2-cyanide (157834-98-5)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, Et₂O, hexane, TMEDA, -70 deg C - -30 deg C, 2.) THF, Et₂O, hexane, TMEDA, r.t., 12 h;

DOI:10.1002/ardp.19943270704

Reference yield: 72.0%

ethane-1,2-dithiol (540-63-6) + 2-(3-methoxyphenyl)-3-(1,5-dithiahexyl)-but-3-enyl-2-cyanide (157834-98-5) → 2-(3-methoxyphenyl)-2-(2-methyldithiolan-2-yl)-propionitrile (157834-99-6)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; for 18h; Ambient temperature;

DOI:10.1002/ardp.19943270704

Reference yield:

2-(3-methoxyphenyl)-3-(1,5-dithiahexyl)-but-3-enyl-2-cyanide (157834-98-5) → 2-(3-methoxyphenyl)-2-(2-methyldithiolan-2-yl)-propylamine (157835-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / BF₃*Et₂O / CH₂Cl₂ / 18 h / Ambient temperature

2: 0.133 g / BH₃*THF-complex / tetrahydrofuran; 1,2-dimethoxy-ethane / 1.) 0 deg C; 2.) r.t., 15 min; 3.) 65 deg C, 1 h; 4.) 105 deg C, 10 h

With borane-THF; boron trifluoride diethyl etherate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;

DOI:10.1002/ardp.19943270704

upstream raw materials:

methyl iodide

Downstream raw materials:

2-(3-methoxyphenyl)-2-(2-methyldithiolan-2-yl)-propionitrile

2-(3-methoxyphenyl)-2-(2-methyldithiolan-2-yl)-propylamine

N-acetyl-2-(3-methoxyphenyl)-2-(2-methyldithiolan-2-yl)propylamine