N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-(3-fluoro-4-methylsulfonyl-phenyl)propionamide

Base Information

Chemical Name:N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-(3-fluoro-4-methylsulfonyl-phenyl)propionamide
CAS No.:1402581-95-6
Molecular Formula:C₂₁H₁₈ClF₄N₃O₃S
Molecular Weight:503.905
Hs Code.:

Synonyms:N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-(3-fluoro-4-methylsulfonyl-phenyl)propionamide

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Chemical Property of N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-(3-fluoro-4-methylsulfonyl-phenyl)propionamide

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Technology Process of N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-(3-fluoro-4-methylsulfonyl-phenyl)propionamide

There total 14 articles about N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-(3-fluoro-4-methylsulfonyl-phenyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1254713-79-5
(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

: 1402586-37-1
2-(3-fluoro-4-(methylsulfonyl)phenyl)propanoic acid

: 1402581-95-6
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-(3-fluoro-4-methylsulfonyl-phenyl)propionamide

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 23 ℃; for 48h; Inert atmosphere;

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1402581-95-6
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-(3-fluoro-4-methylsulfonyl-phenyl)propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 5 h / Reflux

2: N-chloro-succinimide / N,N-dimethyl-formamide / 3.25 h / 23 °C

3: triethylamine / toluene / 20 h / 80 °C

4: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

5: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / tetrahydrofuran / 48 h / 23 °C / Inert atmosphere

With N-chloro-succinimide; ammonia; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 2557-78-0
2-fluorothiophenol

: 1402581-95-6
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-(3-fluoro-4-methylsulfonyl-phenyl)propionamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / 3 h / 23 °C

2.1: aluminum (III) chloride / chloroform / 0 °C

2.2: 4 h / 0 - 23 °C

3.1: sodium hydroxide / toluene / 3 h / 50 °C

3.2: 0 °C

4.1: hydrazine hydrate; potassium hydroxide / 12 h / -50 - 100 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

5.2: 3 h / -78 - 23 °C

6.1: acetone / 2 h / 23 °C

7.1: formic acid; dihydrogen peroxide / 0 - 23 °C

8.1: water; sodium hydroxide / methanol / 2 h / 0 - 23 °C

9.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / tetrahydrofuran / 48 h / 23 °C / Inert atmosphere

With aluminum (III) chloride; formic acid; water; dihydrogen peroxide; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; chloroform; acetone; toluene;