2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethanol

Base Information

• Chemical Name: 2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethanol
• CAS No.: 179397-49-0
• Molecular Formula: C₆₉H₅₉N₅O₅
• Molecular Weight: 1038.26
• Mol file: 179397-49-0.mol

Synonyms:2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethanol

Chemical Property of 2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethanol

There total 1 articles about 2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

[9-((2R,3R,4R,5R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-trityl-amine → 2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethanol (179397-49-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1002/hlca.19960790314

Reference yield:

2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethanol (179397-49-0) → Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester (179397-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / pyridine / 1 h / Ambient temperature

2: 78 percent / hexamethyldisilazane, (NH₄)2SO₄ / CH₂Cl₂

With pyridine; ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane;

DOI:10.1002/hlca.19960790314

Reference yield:

2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethanol (179397-49-0) → Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester (179397-54-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / pyridine / 1 h / Ambient temperature

2: 78 percent / hexamethyldisilazane, (NH₄)2SO₄ / CH₂Cl₂

3: 81 percent / pyridine / 72 h / Ambient temperature

With pyridine; ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane;

DOI:10.1002/hlca.19960790314

Downstream raw materials:

Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester

Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester

Acetic acid 2-{(2R,3R,4R,5R)-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester

Acetic acid 2-{(2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester