Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester

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Chemical Name:Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester
CAS No.:179397-53-6
Molecular Formula:C₂₃H₂₆N₆O₁₀
Molecular Weight:546.494
Hs Code.:

Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester

Synonyms:Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester

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Chemical Property of Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester

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Technology Process of Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester

There total 2 articles about Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 88091-70-7
1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride

: 179397-50-3
3'-O-(2-acetoxyethyl)adenosine

: 179397-53-6
Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester

Guidance literature:: With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane;
DOI:10.1002/hlca.19960790314

Reference yield:

: 179397-49-0
2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethanol

: 179397-53-6
Acetic acid 2-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / pyridine / 1 h / Ambient temperature

2: 78 percent / hexamethyldisilazane, (NH₄)2SO₄ / CH₂Cl₂

With pyridine; ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane;
DOI:10.1002/hlca.19960790314