2-amino-8-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Base Information

Chemical Name:2-amino-8-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
CAS No.:945738-72-7
Molecular Formula:C₃₃H₂₆N₄O₉
Molecular Weight:622.591
Hs Code.:

Synonyms:2-amino-8-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

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Chemical Property of 2-amino-8-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

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Technology Process of 2-amino-8-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

There total 3 articles about 2-amino-8-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 945738-71-6
2-amino-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

: 14215-97-5
1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose

: 945738-72-7
2-amino-8-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: 2-amino-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione; With trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; at 78 ℃;

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 78 ℃; for 18h;
DOI:10.1080/15257770600918912

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 945738-71-6
2-amino-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

: 945738-72-7
2-amino-8-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: 2-amino-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione; With 1,1,1,3,3,3-hexamethyl-disilazane;

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose; trimethylsilyl trifluoromethanesulfonate;

Reference yield:

: 29668-91-5
2-amino-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

: 945738-72-7
2-amino-8-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / acetic acid / palladium on carbon / 30 h / Heating

2.1: trimethylsilyl trifluoromethanesulfonate; hexamethyldisilazane / acetonitrile / 78 °C

2.2: 57 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 18 h / 78 °C

With trimethylsilyl trifluoromethanesulfonate; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; In acetonitrile;
DOI:10.1080/15257770600918912