Pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, 2-amino-

Base Information

• Chemical Name: Pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, 2-amino-
• CAS No.: 945738-71-6
• Molecular Formula: C7H6 N4 O2
• Molecular Weight: 0
• Hs Code.: 2933990090
• Mol file: 945738-71-6.mol

Synonyms:2-amino-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione;

Chemical Property of Pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, 2-amino-

Chemical Property:

• PSA: 104.63000
• LogP: -0.22520

Purity/Quality:

99%min ^*data from raw suppliers

2-amino-Pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, 2-amino-

There total 2 articles about Pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, 2-amino- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-amino-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione (29668-91-5) → 2-amino-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione (945738-71-6)

Guidance literature:

With acetic acid; palladium on activated charcoal; for 30h; Heating;

DOI:10.1080/15257770600918912

Reference yield:

C6H7N3O2 (1378856-68-8) + formamidine acetic acid (3473-63-0) → 2-amino-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione (945738-71-6)

Guidance literature:

Reference yield: 57.0%

2-amino-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione (945738-71-6) + 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (14215-97-5) → 2-amino-8-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione (945738-72-7)

Guidance literature:

2-amino-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione; With trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; at 78 ℃;

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 78 ℃; for 18h;

DOI:10.1080/15257770600918912

upstream raw materials:

2-amino-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

C₆H₇N₃O₂

formamidine acetic acid

Downstream raw materials:

2-amino-8-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Refernces

• 1、 -. "Combined use of IMPDH inhibitors with toll-like receptor agonists". Page/Page column 13. . Retrieved 2010/02/10.