2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4'-acetylaminobiphenyl-4-yl)amide

Base Information

Chemical Name:2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4'-acetylaminobiphenyl-4-yl)amide
CAS No.:1033575-65-3
Molecular Formula:C₂₅H₁₈ClF₃N₄O₂
Molecular Weight:498.892
Hs Code.:

Synonyms:2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4'-acetylaminobiphenyl-4-yl)amide

Suppliers and Price of 2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4'-acetylaminobiphenyl-4-yl)amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4'-acetylaminobiphenyl-4-yl)amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4'-acetylaminobiphenyl-4-yl)amide

There total 6 articles about 2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4'-acetylaminobiphenyl-4-yl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1033586-38-7
N-(4-bromophenyl)-1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

: 101251-09-6
(4-acetylaminophenyl)boronic acid

: 1033575-65-3
2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4'-acetylaminobiphenyl-4-yl)amide

Guidance literature:: With caesium carbonate; DAPCy; In ethanol; at 60 ℃;

Reference yield:

: 437711-24-5
1-(2-Chlorophenyl)-5-(2-furanyl)-3-(trifluoromethyl)-1H-pyrazole

: 1033575-65-3
2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4'-acetylaminobiphenyl-4-yl)amide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium chlorite; sodium dihydrogenphosphate / water; acetonitrile / 42 h / 0 - 20 °C

2: hydrogenchloride / dichloromethane; water

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

4: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

5: caesium carbonate / DAPCy / ethanol / 60 °C

With hydrogenchloride; dmap; sodium chlorite; sodium dihydrogenphosphate; oxalyl dichloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; DAPCy; In ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 437711-25-6
1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

: 1033575-65-3
2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4'-acetylaminobiphenyl-4-yl)amide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3: caesium carbonate / DAPCy / ethanol / 60 °C

With dmap; oxalyl dichloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; DAPCy; In ethanol; dichloromethane;