437711-24-5

Basic information

• Product Name: 1H-Pyrazole, 1-(2-chlorophenyl)-5-(2-furanyl)-3-(trifluoromethyl)-
• CAS NO: 437711-24-5
• Molecular Formula: C14H8ClF3N2O
• Molecular Weight: 312.679
• Mol File: 437711-24-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole, 1-(2-chlorophenyl)-5-(2-furanyl)-3-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole, 1-(2-chlorophenyl)-5-(2-furanyl)-3-(trifluoromethyl)-(437711-24-5)
• EPA Substance Registry System: 1H-Pyrazole, 1-(2-chlorophenyl)-5-(2-furanyl)-3-(trifluoromethyl)-(437711-24-5)

Safety Data

• Hazardous Substances Data: 437711-24-5(Hazardous Substances Data)

Usage

Compound type

pyrazole derivative

+ Five-membered heterocyclic ring

yes

+ Two nitrogen atoms at adjacent positions

yes

+ 2-chlorophenyl group

yes

+ 2-furanyl group

yes

+ Trifluoromethyl group

yes

Usage

pharmaceutical research and development, potential therapeutic applications

Pharmacological properties

diverse

Upstream product

• 326-90-9 4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione 
• 10449-07-7 (2-chlorophenyl)hydrazine 
• 41052-75-9 o-chlorophenylhydrazine hydrochloride 
• 1192-62-7 1-(2-furyl)-1-ethanone 

Downstream Products

• 437711-25-6 1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid 
• 1033586-27-4 [2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]methanol 
• 1033586-28-5 5-bromomethyl-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole 
• 1033586-39-8 2-(1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)acetonitrile 
• 1033586-26-3 2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid ethyl ester 
• 1033586-96-7 C₁₂H₇Cl₂F₃N₂O 
• 1033586-41-2 2-(1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)acetic acid 
• 1033574-41-2 5-(4-bromophenoxymethyl)-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole 
• 1033586-42-3 4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline 
• 1033586-38-7 N-(4-bromophenyl)-1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 1033575-66-4 2-[2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-N-quinolin-6-ylacetamide 
• 1033575-56-2 2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid 3-methanesulfonyl-benzylamide 
• 1033574-89-8 1-(2-chlorophenyl)-5-(3'-methanesulfonylbiphenyl-4-yloxymethyl)-3-trifluoromethyl-1H-pyrazole 
• 1033575-67-5 N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-N-methyl-3'-(methylsulfonyl)biphenyl-4-amine 

Relevant articles and documents

LXR AND FXR MODULATORS

Compounds of the invention are disclosed, such as compounds of formulae LX - LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R00, R200, R400, R500, J11, J21, G1, G21, and Q are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.

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