4,10-bis(deacetyl)-7-triethylsily-13-((4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinyl)baccatin III

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Chemical Name:4,10-bis(deacetyl)-7-triethylsily-13-((4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinyl)baccatin III
CAS No.:160768-74-1
Molecular Formula:C₅₀H₆₉NO₁₃Si
Molecular Weight:920.182
Hs Code.:

Synonyms:4,10-bis(deacetyl)-7-triethylsily-13-((4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinyl)baccatin III

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Chemical Property of 4,10-bis(deacetyl)-7-triethylsily-13-((4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinyl)baccatin III

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Technology Process of 4,10-bis(deacetyl)-7-triethylsily-13-((4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinyl)baccatin III

There total 2 articles about 4,10-bis(deacetyl)-7-triethylsily-13-((4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinyl)baccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 144654-43-3
4,10-bis(deacetyl)-7-(triethylsily)baccatin III

: 143615-03-6,143527-70-2
(4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

: 160768-74-1
4,10-bis(deacetyl)-7-triethylsily-13-((4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinyl)baccatin III

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In toluene;
DOI:10.1016/0040-4039(94)85018-6

Reference yield:

: 115437-21-3
7-(triethylsilyl)baccatin III

: 160768-74-1
4,10-bis(deacetyl)-7-triethylsily-13-((4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinyl)baccatin III

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / potassium tert-butoxide / tetrahydrofuran

2: 90 percent / DCC, DMAP / toluene

With dmap; potassium tert-butylate; dicyclohexyl-carbodiimide; In tetrahydrofuran; toluene;
DOI:10.1016/0040-4039(94)85018-6