144654-43-3

Upstream product

• 115437-18-8 7-triethylsilyl-10-deacetylbaccatin III 
• 115437-21-3 7-(triethylsilyl)baccatin III 

Downstream Products

• 175444-21-0 C₃₃H₄₆O₉Si 
• 160511-43-3 4-deacetyl-7-(triethylsilyl)baccatin III 13-<(4S,5R)-3-(tert-butoxycarbonyl)-5-carboxyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine> 
• 160511-44-4 4-deacetyl-N-debenzoyltaxol 
• 175444-23-2 C₅₅H₇₃NO₁₄Si 
• 175444-20-9 C₃₃H₅₀O₉Si 
• 175444-22-1 C₃₃H₄₈O₉Si 
• 160768-74-1 4,10-bis(deacetyl)-7-triethylsily-13-((4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinyl)baccatin III 

Relevant academic research and scientific papers

Taxoids: 11,12-dihydro-4-deacetyldocetaxel

11,12-dihydro-4-deacetyldocetaxel was prepared from 10-deacetylbaccatin III via its reduced derivative at C11, C12. The title compound is not active in microtubules disassembly.

Synthesis and Biological Evaluation of 4-Deacetylpaclitaxel

4-Deacetylpaclitaxel, prepared from baccatin III via two synthetic approaches and from paclitaxel via one synthetic approach, has minimal effects on tubulin polymerization and is not cytotoxic to human CA46 Burkitt lymphoma cells.

Rearrangement reactions of taxanes: Structural modifications of 10-deacetylbaccatin III

10-Deacetylbaccatin III 2 is a taxane diterpenoid isolated from the plant genus Taxus, which has been used for the partial synthesis of the antitumor compounds taxol and taxotere. A number of structural modifications have been performed on 2 under acidic