7-iodo-5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Base Information

Chemical Name:7-iodo-5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine
CAS No.:1422772-47-1
Molecular Formula:C₂₂H₂₀IN₃O₅S
Molecular Weight:565.388
Hs Code.:

Synonyms:7-iodo-5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Suppliers and Price of 7-iodo-5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-iodo-5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-iodo-5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

There total 4 articles about 7-iodo-5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.4%

: 1422772-46-0
7-iodo-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine

: 98-59-9
p-toluenesulfonyl chloride

: 1422772-47-1
7-iodo-5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: 7-iodo-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.25h;

p-toluenesulfonyl chloride; In tetrahydrofuran; mineral oil; for 18h;
DOI:10.1021/jm301720p

Reference yield:

: 1422772-45-9
2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine

: 1422772-47-1
7-iodo-5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.67 h / 20 °C

1.2: 0.5 h

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h

2.2: 18 h

With sodium hydride; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm301720p

Reference yield:

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1422772-47-1
7-iodo-5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 18 h / 110 °C

2.1: potassium hydroxide / N,N-dimethyl-formamide / 0.67 h / 20 °C

2.2: 0.5 h

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h

3.2: 18 h

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; potassium carbonate; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm301720p