5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

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Chemical Name:5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide
CAS No.:1422772-48-2
Molecular Formula:C₂₆H₂₈N₄O₆S
Molecular Weight:524.598
Hs Code.:

Synonyms:5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

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Chemical Property of 5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

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Technology Process of 5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

There total 5 articles about 5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 201230-82-2
carbon monoxide

: 1422772-47-1
7-iodo-5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

: 75-31-0
isopropylamine

: 1422772-48-2
5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

Guidance literature:: carbon monoxide; 7-iodo-5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine; With palladium diacetate; potassium carbonate; In toluene; at 100 ℃; for 0.25h;

isopropylamine; In toluene;
DOI:10.1021/jm301720p

Reference yield:

: 1422772-45-9
2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine

: 1422772-48-2
5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.67 h / 20 °C

1.2: 0.5 h

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h

2.2: 18 h

3.1: potassium carbonate; palladium diacetate / toluene / 0.25 h / 100 °C

With palladium diacetate; sodium hydride; potassium carbonate; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm301720p

Reference yield:

: 1422772-46-0
7-iodo-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine

: 1422772-48-2
5-(toluene-4-sulfonyl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h

1.2: 18 h

2.1: potassium carbonate; palladium diacetate / toluene / 0.25 h / 100 °C

With palladium diacetate; sodium hydride; potassium carbonate; In tetrahydrofuran; toluene; mineral oil;
DOI:10.1021/jm301720p