1-[1-({5-[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

Base Information

Chemical Name:1-[1-({5-[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one
CAS No.:1095273-37-2
Molecular Formula:C₂₆H₂₉ClN₈O₃
Molecular Weight:537.021
Hs Code.:

Synonyms:1-[1-({5-[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

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Chemical Property of 1-[1-({5-[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

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Technology Process of 1-[1-({5-[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

There total 9 articles about 1-[1-({5-[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 185961-99-3
1-(piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

: 1095274-50-2
{5-[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid

: 1095273-37-2
1-[1-({5-[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 896466-67-4
3-chloro-5-(4-methylpiperazin-1-yl)benzonitrile

: 1095273-37-2
1-[1-({5-[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / ethanol; water / 2.5 h / Heating / reflux

2.1: sulfuric acid / 96 h / Heating / reflux

2.2: 20 °C / pH 7 - 8

3.1: hydrazine / ethanol / 4 h / Heating / reflux

4.1: tetrahydrofuran / 0.5 h / 20 °C

5.1: Burgess Reagent / dichloromethane / 0.17 h / 100 °C / Microwave irradition

6.1: sodium hydroxide; water / ethanol / 0.33 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With sodium hydroxide; Burgess Reagent; sulfuric acid; water; N-ethyl-N,N-diisopropylamine; HATU; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 327056-73-5
3-fluoro-5-chlorobenzonitrile

: 1095273-37-2
1-[1-({5-[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / dimethyl sulfoxide / 20 - 80 °C

2.1: sodium hydroxide / ethanol; water / 2.5 h / Heating / reflux

3.1: sulfuric acid / 96 h / Heating / reflux

3.2: 20 °C / pH 7 - 8

4.1: hydrazine / ethanol / 4 h / Heating / reflux

5.1: tetrahydrofuran / 0.5 h / 20 °C

6.1: Burgess Reagent / dichloromethane / 0.17 h / 100 °C / Microwave irradition

7.1: sodium hydroxide; water / ethanol / 0.33 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With sodium hydroxide; Burgess Reagent; sulfuric acid; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;