lithium [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

Base Information

Chemical Name:lithium [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate
CAS No.:1251957-76-2
Molecular Formula:C₂₅H₃₇N₂O₃Si*Li
Molecular Weight:448.607
Hs Code.:

Synonyms:lithium [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

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Chemical Property of lithium [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

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Technology Process of lithium [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

There total 7 articles about lithium [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1251957-75-1
ethyl [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

: 1251957-76-2
lithium [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; ethanol; water; at 20 ℃; for 18h;
DOI:10.1021/op1001462

Reference yield:

: 808768-89-0
ethyl [4-(2-amino-2-methylpropyl)phenyl]acetate

: 1251957-76-2
lithium [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / propiononitrile / 18 h / 110 °C

2: 5% Pd(II)/C(eggshell); hydrogen; sodium acetate / ethanol / 40 °C / 2068.65 Torr

3: lithium hydroxide / tetrahydrofuran; ethanol; water / 18 h / 20 °C

With 5% Pd(II)/C(eggshell); hydrogen; sodium acetate; potassium carbonate; potassium iodide; lithium hydroxide; In tetrahydrofuran; ethanol; water; propiononitrile;
DOI:10.1021/op1001462

Reference yield:

: 1251957-72-8
tert-butyl [2-(4-bromophenyl)-1,1-dimethylethyl]carbamate

: 1251957-76-2
lithium [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate; palladium diacetate; johnphos / toluene / 100 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; ethanol / 20 °C

2.2: pH 8

3.1: potassium carbonate; potassium iodide / propiononitrile / 18 h / 110 °C

4.1: 5% Pd(II)/C(eggshell); hydrogen; sodium acetate / ethanol / 40 °C / 2068.65 Torr

5.1: lithium hydroxide / tetrahydrofuran; ethanol; water / 18 h / 20 °C

With hydrogenchloride; potassium phosphate; 5% Pd(II)/C(eggshell); hydrogen; sodium acetate; palladium diacetate; potassium carbonate; potassium iodide; lithium hydroxide; johnphos; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene; propiononitrile;
DOI:10.1021/op1001462