ethyl [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(6-chloropyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

Base Information

Chemical Name:ethyl [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(6-chloropyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate
CAS No.:1251957-74-0
Molecular Formula:C₂₇H₄₁ClN₂O₃Si
Molecular Weight:505.173
Hs Code.:

Synonyms:ethyl [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(6-chloropyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

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Chemical Property of ethyl [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(6-chloropyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

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Technology Process of ethyl [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(6-chloropyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

There total 4 articles about ethyl [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(6-chloropyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 808768-89-0
ethyl [4-(2-amino-2-methylpropyl)phenyl]acetate

: 364080-73-9
(R)-toluene-4-sulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl ester

: 1251957-74-0
ethyl [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(6-chloropyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

Guidance literature:: With potassium carbonate; potassium iodide; In propiononitrile; at 110 ℃; for 18h;
DOI:10.1021/op1001462

Reference yield:

: 1251957-72-8
tert-butyl [2-(4-bromophenyl)-1,1-dimethylethyl]carbamate

: 1251957-74-0
ethyl [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(6-chloropyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate; palladium diacetate; johnphos / toluene / 100 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; ethanol / 20 °C

2.2: pH 8

3.1: potassium carbonate; potassium iodide / propiononitrile / 18 h / 110 °C

With hydrogenchloride; potassium phosphate; palladium diacetate; potassium carbonate; potassium iodide; johnphos; In 1,4-dioxane; ethanol; toluene; propiononitrile;
DOI:10.1021/op1001462

Reference yield:

: 1463-08-7
C₁₀H₁₄BrN*ClH

: 1251957-74-0
ethyl [4-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(6-chloropyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 2-methyltetrahydrofuran / 18 h / 20 °C / Cooling with ice

2.1: potassium phosphate; palladium diacetate; johnphos / toluene / 100 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; ethanol / 20 °C

3.2: pH 8

4.1: potassium carbonate; potassium iodide / propiononitrile / 18 h / 110 °C

With hydrogenchloride; potassium phosphate; palladium diacetate; potassium carbonate; triethylamine; potassium iodide; johnphos; In 2-methyltetrahydrofuran; 1,4-dioxane; ethanol; toluene; propiononitrile;
DOI:10.1021/op1001462