m-Tyramine

Base Information

• Chemical Name: m-Tyramine
• CAS No.: 588-05-6
• Molecular Formula: C8H12ClNO
• Molecular Weight: 137.181
• Hs Code.: 2922299090
• European Community (EC) Number: 671-526-1
• UNII: K1OA38R0EZ
• DSSTox Substance ID: DTXSID50207522
• Nikkaji Number: J259.678D
• Wikipedia: Meta-Tyramine
• Wikidata: Q6553277
• Metabolomics Workbench ID: 38688
• ChEMBL ID: CHEMBL145584
• Mol file: 588-05-6.mol

Synonyms:3-hydroxyphenylethylamine;3-tyramine;3-tyramine hydrobromide;3-tyramine hydrochloride;m-tyramine;meta-tyramine

Chemical Property of m-Tyramine

Chemical Property:

• Melting Point: 140 °C
• Boiling Point: 275.5 °C at 760 mmHg
• PKA: 9.58±0.10(Predicted)
• Flash Point: 120.4 °C
• PSA: 46.25000
• Density: 1.103±0.06 g/cm3(Predicted)
• LogP: 1.59370
• Solubility.: H2O: ≥10 mg/mL
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 95.3

Purity/Quality:

98%min ^*data from raw suppliers

m-Tyramine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)O)CCN
• Uses: Tyramine is an endogenous compound which exists in the brain as a trace amine but is also an exogenous compound which is found in foods such as cheese and wine.

Technology Process of m-Tyramine

There total 14 articles about m-Tyramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

→ m-tyramine (588-05-6)

Guidance literature:

Reference yield: 91.0%

C18H31NO3Si → m-tyramine (588-05-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jo990272o

Reference yield: 68.9%

2-(3-benzyloxyphenyl)ethylamine (51061-22-4) → m-tyramine (588-05-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 1.5h; under 760 Torr;

upstream raw materials:

3-hydroxy-β-nitrostyrene

α,3-dihydroxybenzeneacetonitrile

2-(3-benzyloxyphenyl)ethylamine

3-Benzyloxybenzaldehyde

Downstream raw materials:

rac-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

2-<<2-(3-hydroxyphenyl)ethyl>amino>-1,4-naphthoquinone

N-(t-butoxycarbonyl)-2-(3-hydroxyphenyl)-ethylamine

6-hydroxy-1-phenyl-1,2,3,4-tetrahydro-isoquinoline

Refernces

• 1、 Wang, Yu,Tappertzhofen, Nadine,Méndez-Sánchez, Daniel,Bawn, Maria,Lyu, Boyu,Ward, John M.,Hailes, Helen C.. "Design and Use of de novo Cascades for the Biosynthesis of New Benzylisoquinoline Alkaloids". supporting information. p. 10120 - 10125. Retrieved 2019/06/27.
• 2、 Ma, Dawei,Wu, Wengen,Yang, Guoxin,Li, Jingya,Li, Jia,Ye, Qizhuang. "Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors". . p. 47 - 50. Retrieved 2007/10/03.