N-([2-⁽²⁾H]-1-(2-phenylethyl)-4-piperidinyl)aniline

Base Information

• Chemical Name: N-([2-⁽²⁾H]-1-(2-phenylethyl)-4-piperidinyl)aniline
• CAS No.: 1254229-85-0
• Molecular Formula: C₁₉H₂₄N₂
• Molecular Weight: 281.405
• Mol file: 1254229-85-0.mol

Synonyms:N-([2-⁽²⁾H]-1-(2-phenylethyl)-4-piperidinyl)aniline

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Chemical Property of N-([2-⁽²⁾H]-1-(2-phenylethyl)-4-piperidinyl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-([2-⁽²⁾H]-1-(2-phenylethyl)-4-piperidinyl)aniline

There total 4 articles about N-([2-⁽²⁾H]-1-(2-phenylethyl)-4-piperidinyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.3%

C22H27(2)HN2O (1254229-86-1) → N-([2-(2)H]-1-(2-phenylethyl)-4-piperidinyl)aniline (1254229-85-0)

Guidance literature:

C₂₂H₂₇⁽²⁾HN₂O; With hydrogenchloride; water; at 100 ℃; for 72h;

With ammonium hydroxide;

DOI:10.1002/rcm.4673

Reference yield:

N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]propanamide (437-38-7) → N-([2-(2)H]-1-(2-phenylethyl)-4-piperidinyl)aniline (1254229-85-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / 1 h / 0 °C

2: dichloromethane / 0 °C / Inert atmosphere

3: methanol; sodium borodeuteride / 4 h / 0 °C / Inert atmosphere

4: hydrogenchloride; water / 72 h / 100 °C

With hydrogenchloride; methanol; sodium borodeuteride; water; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1002/rcm.4673

Reference yield:

fentanyl N-oxide (85893-37-4) → N-([2-(2)H]-1-(2-phenylethyl)-4-piperidinyl)aniline (1254229-85-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 0 °C / Inert atmosphere

2: methanol; sodium borodeuteride / 4 h / 0 °C / Inert atmosphere

3: hydrogenchloride; water / 72 h / 100 °C

With hydrogenchloride; methanol; sodium borodeuteride; water; In dichloromethane;

DOI:10.1002/rcm.4673

upstream raw materials:

C₂₂H₂₇⁽²⁾HN₂O

N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]propanamide

fentanyl N-oxide

Refernces