Diphenyl-carbamic acid 2-acetylamino-9-({benzyl-[2-((1S,2S,6R,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-carbamoyl}-methyl)-9H-purin-6-yl ester

Base Information

• Chemical Name: Diphenyl-carbamic acid 2-acetylamino-9-({benzyl-[2-((1S,2S,6R,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-carbamoyl}-methyl)-9H-purin-6-yl ester
• CAS No.: 406215-20-1
• Molecular Formula: C₄₀H₃₆N₈O₆
• Molecular Weight: 724.776

Synonyms:Diphenyl-carbamic acid 2-acetylamino-9-({benzyl-[2-((1S,2S,6R,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-carbamoyl}-methyl)-9H-purin-6-yl ester

Chemical Property of Diphenyl-carbamic acid 2-acetylamino-9-({benzyl-[2-((1S,2S,6R,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-carbamoyl}-methyl)-9H-purin-6-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diphenyl-carbamic acid 2-acetylamino-9-({benzyl-[2-((1S,2S,6R,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-carbamoyl}-methyl)-9H-purin-6-yl ester

There total 7 articles about Diphenyl-carbamic acid 2-acetylamino-9-({benzyl-[2-((1S,2S,6R,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-carbamoyl}-methyl)-9H-purin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N2-acetyl-O6-(diphenylcarbamoyl)guanine (112233-74-6) + N-benzyl-2-chloro-N-[2-(3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl]-acetamide (406215-05-2) → Diphenyl-carbamic acid 2-acetylamino-9-({benzyl-[2-((1S,2S,6R,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl]-carbamoyl}-methyl)-9H-purin-6-yl ester (406215-20-1)

Guidance literature:

N₂-acetyl-O₆-(diphenylcarbamoyl)guanine; With sodium hydride; In N,N-dimethyl-formamide;

N-benzyl-2-chloro-N-[2-(3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-acetamide; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; Further stages.;

Reference yield:

benzaldehyde (100-52-7) → Diphenyl-carbamic acid 2-acetylamino-9-({benzyl-[2-((1S,2S,6R,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl]-carbamoyl}-methyl)-9H-purin-6-yl ester (406215-20-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 100 percent / Et₃N; MgSO₄ / CH₂Cl₂

2.1: 54 percent / NaBH₃CN; AcOH / methanol / 4 h

3.1: 90 percent / Et₃N / CH₂Cl₂

4.1: NaH / dimethylformamide

4.2: 71 percent / tetrabutylammonium iodide / dimethylformamide

With sodium hydride; sodium cyanoborohydride; magnesium sulfate; acetic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(1R,2R,6S,7S)-4-oxa-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (2746-19-2) → Diphenyl-carbamic acid 2-acetylamino-9-({benzyl-[2-((1S,2S,6R,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl]-carbamoyl}-methyl)-9H-purin-6-yl ester (406215-20-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 92 percent / toluene / 64 h / Heating

2.1: 86 percent / CH₂Cl₂

3.1: 100 percent / Et₃N; MgSO₄ / CH₂Cl₂

4.1: 54 percent / NaBH₃CN; AcOH / methanol / 4 h

5.1: 90 percent / Et₃N / CH₂Cl₂

6.1: NaH / dimethylformamide

6.2: 71 percent / tetrabutylammonium iodide / dimethylformamide

With sodium hydride; sodium cyanoborohydride; magnesium sulfate; acetic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

N₂-acetyl-O₆-(diphenylcarbamoyl)guanine

N-benzyl-2-chloro-N-[2-(3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-acetamide

benzaldehyde

(1R,2R,6S,7S)-4-oxa-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 406215-20-1 Diphenyl-carbamic acid 2-acetylamino-9-({benzyl-[2-((1S,2S,6R,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-carbamoyl}-methyl)-9H-purin-6-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send