2-[[3,5-dimethoxy-4-(3-methyl-2-butenyl)]phenyl]-6-(tert-butyldimethylsilanyloxy)benzofuran

Base Information

Chemical Name:2-[[3,5-dimethoxy-4-(3-methyl-2-butenyl)]phenyl]-6-(tert-butyldimethylsilanyloxy)benzofuran
CAS No.:218444-39-4
Molecular Formula:C₂₇H₃₆O₄Si
Molecular Weight:452.666
Hs Code.:

Synonyms:2-[[3,5-dimethoxy-4-(3-methyl-2-butenyl)]phenyl]-6-(tert-butyldimethylsilanyloxy)benzofuran

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Chemical Property of 2-[[3,5-dimethoxy-4-(3-methyl-2-butenyl)]phenyl]-6-(tert-butyldimethylsilanyloxy)benzofuran

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Technology Process of 2-[[3,5-dimethoxy-4-(3-methyl-2-butenyl)]phenyl]-6-(tert-butyldimethylsilanyloxy)benzofuran

There total 19 articles about 2-[[3,5-dimethoxy-4-(3-methyl-2-butenyl)]phenyl]-6-(tert-butyldimethylsilanyloxy)benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 870-63-3
prenyl bromide

: 218444-38-3
2-(3,5-dimethoxyphenyl)-6-(tert-butyl-dimethylsilanyloxy)benzofuran

: 218444-39-4
2-[[3,5-dimethoxy-4-(3-methyl-2-butenyl)]phenyl]-6-(tert-butyldimethylsilanyloxy)benzofuran

Guidance literature:: 2-(3,5-dimethoxyphenyl)-6-(tert-butyl-dimethylsilanyloxy)benzofuran; With n-butyllithium; In hexane; cyclohexane; for 0.5h; Inert atmosphere; Heating;

prenyl bromide; In hexane; cyclohexane; for 2h; Inert atmosphere; Heating;
DOI:10.1016/j.tetlet.2015.05.093

Reference yield:

: 6272-26-0
6-hydroxybenzofuran-3-one

: 218444-39-4
2-[[3,5-dimethoxy-4-(3-methyl-2-butenyl)]phenyl]-6-(tert-butyldimethylsilanyloxy)benzofuran

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / tetrahydrofuran / 4 h / 0 - 20 °C

2.1: sodium tetrahydroborate / methanol / 4 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: -78 - 20 °C

3.3: 20 °C / pH 5

4.1: potassium carbonate; palladium diacetate; tricyclohexylphosphine / water; 1,2-dimethoxyethane / 2 h / 80 °C / Inert atmosphere

5.1: 1H-imidazole / tetrahydrofuran / 2 h / 20 °C

6.1: n-butyllithium / hexane; cyclohexane / 0.5 h / Inert atmosphere; Heating

6.2: 2 h / Inert atmosphere; Heating

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; palladium diacetate; potassium carbonate; tricyclohexylphosphine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; cyclohexane; water;
DOI:10.1016/j.tetlet.2015.05.093

Reference yield:

: 134937-20-5
2-(3,5-dimethoxyphenyl)-6-hydroxybenzofuran

: 218444-39-4
2-[[3,5-dimethoxy-4-(3-methyl-2-butenyl)]phenyl]-6-(tert-butyldimethylsilanyloxy)benzofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

With 1H-imidazole; In N,N-dimethyl-formamide;