Amitriptyline

Base Information Edit

Chemical Name:Amitriptyline
CAS No.:50-48-6
Molecular Formula:C20H23N
Molecular Weight:277.409
Hs Code.:2921499090
European Community (EC) Number:200-041-6
UNII:1806D8D52K
DSSTox Substance ID:DTXSID7022594
Nikkaji Number:J4.103C
Wikipedia:Amitriptyline
Wikidata:Q58397
NCI Thesaurus Code:C62005
RXCUI:704
Pharos Ligand ID:V5NVUP34ATWH
Metabolomics Workbench ID:42706
ChEMBL ID:CHEMBL629
Mol file:50-48-6.mol

Synonyms:Amineurin;Amitrip;Amitriptylin beta;Amitriptylin Desitin;Amitriptylin neuraxpharm;Amitriptylin RPh;Amitriptylin-neuraxpharm;Amitriptyline;Amitriptyline Hydrochloride;Amitrol;Anapsique;Apo Amitriptyline;Apo-Amitriptyline;Damilen;Desitin, Amitriptylin;Domical;Elavil;Endep;Laroxyl;Lentizol;Novoprotect;RPh, Amitriptylin;Saroten;Sarotex;Syneudon;Triptafen;Tryptanol;Tryptine;Tryptizol

Suppliers and Price of Amitriptyline

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Amitriptyline
500ul
$ 393.00

DC Chemicals
Amitriptyline；MK-230,N-750,Ro41575 >98%
1 g
$ 600.00

Biorbyt Ltd
Amitriptyline >98%
250 mg
$ 606.90

Biorbyt Ltd
Amitriptyline >98%
100 mg
$ 397.80

American Custom Chemicals Corporation
AMITRIPTYLINE 95.00%
500MG
$ 403.20

Total 65 raw suppliers

Chemical Property of Amitriptyline Edit

Chemical Property:

Melting Point:196-197 °C
Refractive Index:1.7500 (estimate)
Boiling Point:398.2 °C at 760 mmHg
PKA:9.4(at 25℃)
Flash Point:174 °C
PSA：3.24000
Density:1.076 g/cm³
LogP:4.97060
Water Solubility.:9.7 mg/mL
XLogP3:5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:277.183049738
Heavy Atom Count:21
Complexity:331

Purity/Quality:

99.9% ^*data from raw suppliers

Amitriptyline ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Antidepressant Agents
Canonical SMILES:CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
Recent ClinicalTrials:Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines
Recent EU Clinical Trials:Management of diarrhoea in ulcerative colitis: multi-arm multi-stage trial of low FODMAP diet, amitriptyline, ondansetron, or loperamide: MODULATE.
Recent NIPH Clinical Trials:Clinical evaluation on the pain-reducing effect of Aconinsan for burning mouth syndrome
Uses Antidepressant. Amitriptyline is used for anxious-depressive conditions. It is easier to tolerate than imipramine.
Therapeutic Function Antidepressant
Biological Functions Amitriptyline is a tertiary amine dibenzocycloheptadiene TCA with a propylidene side chain extending from the central carbocyclic ring. The diarylpropylideneamine moiety for amitriptyline makes it sensitive to photo-oxidation; therefore, its hydrochloride solutions should be protected from light to avoid ketone formation and precipitation.

Technology Process of Amitriptyline

There total 15 articles about Amitriptyline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%