4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoic acid

Base Information

Chemical Name:4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoic acid
CAS No.:945452-29-9
Molecular Formula:C₁₅H₁₅N₅O₂S
Molecular Weight:329.382
Hs Code.:

Synonyms:4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoic acid

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Chemical Property of 4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoic acid

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Technology Process of 4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoic acid

There total 1 articles about 4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1074-36-8
4-mercaptobenzoic acid

: 170170-14-6
2,4-Diamino-5-ethylpyrrolo<2,3-d>pyrimidine

: 945452-29-9
4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoic acid

Guidance literature:: With iodine; In ethanol; water; Heating;
DOI:10.1021/jm070165j

Reference yield: 85.0%

: 945452-29-9
4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 945452-30-2
diethyl N-{4-[(5-ethyl-2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamate

Guidance literature:: 4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoic acid; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

With isobutyl chloroformate; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

diethyl-L-glutamate hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Further stages.;
DOI:10.1021/jm070165j

Reference yield:

: 945452-29-9
4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoic acid

: C₂₀H₂₂N₆O₅S

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N / dimethylformamide / 0.08 h / 20 °C

1.2: isobutyl chloroformate / dimethylformamide / 0.5 h / 0 °C

1.3: 85 percent / Et₃N / dimethylformamide / 24 h / 20 °C

2.1: 88 percent / aq. NaOH / methanol / 16 h / 20 °C

With sodium hydroxide; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm070165j