tert-butyl ((1R)-1-methyl-1-oxiran-2-yl-2-phenylethyl)carbamate

Base Information

• Chemical Name: tert-butyl ((1R)-1-methyl-1-oxiran-2-yl-2-phenylethyl)carbamate
• CAS No.: 868286-73-1
• Molecular Formula: C₁₆H₂₃NO₃
• Molecular Weight: 277.364
• Mol file: 868286-73-1.mol

Synonyms:tert-butyl ((1R)-1-methyl-1-oxiran-2-yl-2-phenylethyl)carbamate

Chemical Property of tert-butyl ((1R)-1-methyl-1-oxiran-2-yl-2-phenylethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl ((1R)-1-methyl-1-oxiran-2-yl-2-phenylethyl)carbamate

There total 3 articles about tert-butyl ((1R)-1-methyl-1-oxiran-2-yl-2-phenylethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethylsulphonium iodide (2181-42-2) + tert-butyl ((1R)-1-benzyl-1-methyl-2-oxoethyl)carbamate (677005-07-1) → tert-butyl ((1R)-1-methyl-1-oxiran-2-yl-2-phenylethyl)carbamate (868286-73-1)

Guidance literature:

With potassium hydroxide; In acetonitrile; at 20 - 60 ℃; for 3h; Sealed tube;

Reference yield:

tert-butyl (R)-(1-hydroxy-2-methyl-3-phenylpropan-2-yl)carbamate (868286-68-4) → tert-butyl ((1R)-1-methyl-1-oxiran-2-yl-2-phenylethyl)carbamate (868286-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; pyridine-SO₃ complex / dichloromethane; dimethyl sulfoxide

2: potassium hydroxide / acetonitrile / 3 h / 20 - 60 °C / Sealed tube

With pyridine-SO₃ complex; triethylamine; potassium hydroxide; In dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl ((1R)-1-methyl-1-oxiran-2-yl-2-phenylethyl)carbamate (868286-73-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 16 h / 20 °C

2: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 3.5 h / 20 °C

3: potassium hydroxide; water / acetonitrile / 4.5 h / 60 °C

With potassium hydroxide; water; sulfur trioxide pyridine complex; triethylamine; In dichloromethane; dimethyl sulfoxide; acetonitrile;

upstream raw materials:

trimethylsulphonium iodide

tert-butyl ((1R)-1-benzyl-1-methyl-2-oxoethyl)carbamate

tert-butyl (R)-(1-hydroxy-2-methyl-3-phenylpropan-2-yl)carbamate

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl ((1R)-3-amino-1-benzyl-2-hydroxy-1-methylpropyl)carbamate

tert-butyl (3R-amino-1-benzyl-2RS-hydroxy-1-methylpropyl)carbamate