677005-07-1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 17350-84-4 (R)-2-amino-2-methyl-3-phenylpropanoic acid 
• 21394-38-7 (2R)-2-amino-2-methyl-3-phenyl-propan-1-ol 
• 868286-68-4 tert-butyl (R)-(1-hydroxy-2-methyl-3-phenylpropan-2-yl)carbamate 
• 22435-99-0 ethyl (R)-2-amino-2-methyl-3-phenylpropanoate 
• 677005-06-0 2-tert-butoxycarbonylamino-2-methyl-3-phenyl-propionic acid ethyl ester 

Downstream Products

• 868286-73-1 tert-butyl ((1R)-1-methyl-1-oxiran-2-yl-2-phenylethyl)carbamate 
• 868286-72-0 tert-butyl ((1R)-3-amino-1-benzyl-2-hydroxy-1-methylpropyl)carbamate 
• 868286-72-0 tert-butyl (3R-amino-1-benzyl-2RS-hydroxy-1-methylpropyl)carbamate 

Relevant academic research and scientific papers

OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF

The invention provides novel beta-secretase inhibitors and methods for their including methods of treating Alzheimer's disease.

2, 4, 6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE

The present invention is directed to 2, 4, 6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer’s disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

1,3,5-SUBSTITUTED PHENYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

Highly enantioselective alkylation of glycine methyl and ethyl ester derivatives under phase-transfer conditions: Its synthetic advantage

Phase-transfer alkylation of the benzophenone Schiff base of glycine methyl or ethyl ester (2) was found to be catalyzed by 3,4,5-F 3-C6H2-NAS-Br [(S,S)-1] with high efficiency and excellent enantioselectivity. This procedure allows facile derivatization of the resulting alkylation products to other synthetically useful chiral building blocks.