1-[2-(4-{4-[1-(4-fluorophenyl)methylidene]-5-oxo-4,5-dihydro-1,3-oxazol-2-yl}phenyl)-1-diazenyl]-2-naphthyl acetate

Base Information

• Chemical Name: 1-[2-(4-{4-[1-(4-fluorophenyl)methylidene]-5-oxo-4,5-dihydro-1,3-oxazol-2-yl}phenyl)-1-diazenyl]-2-naphthyl acetate
• CAS No.: 1428486-03-6
• Molecular Formula: C₂₈H₁₈FN₃O₄
• Molecular Weight: 479.467
• Mol file: 1428486-03-6.mol

Synonyms:1-[2-(4-{4-[1-(4-fluorophenyl)methylidene]-5-oxo-4,5-dihydro-1,3-oxazol-2-yl}phenyl)-1-diazenyl]-2-naphthyl acetate

Chemical Property of 1-[2-(4-{4-[1-(4-fluorophenyl)methylidene]-5-oxo-4,5-dihydro-1,3-oxazol-2-yl}phenyl)-1-diazenyl]-2-naphthyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(4-{4-[1-(4-fluorophenyl)methylidene]-5-oxo-4,5-dihydro-1,3-oxazol-2-yl}phenyl)-1-diazenyl]-2-naphthyl acetate

There total 3 articles about 1-[2-(4-{4-[1-(4-fluorophenyl)methylidene]-5-oxo-4,5-dihydro-1,3-oxazol-2-yl}phenyl)-1-diazenyl]-2-naphthyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

sodium 2-({4-[2-(2-hydroxy-1-naphthyl)-1-diazenyl]benzoyl}amino)acetate (1428486-06-9) + acetic anhydride (108-24-7) + 4-fluorobenzaldehyde (459-57-4) → 1-[2-(4-{4-[1-(4-fluorophenyl)methylidene]-5-oxo-4,5-dihydro-1,3-oxazol-2-yl}phenyl)-1-diazenyl]-2-naphthyl acetate (1428486-03-6)

Guidance literature:

With sodium acetate; at 100 ℃;

DOI:10.1016/j.bmc.2013.01.014

Reference yield:

p-Aminohippuric acid (61-78-9) → 1-[2-(4-{4-[1-(4-fluorophenyl)methylidene]-5-oxo-4,5-dihydro-1,3-oxazol-2-yl}phenyl)-1-diazenyl]-2-naphthyl acetate (1428486-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate / Reflux

1.2: Cooling with ice

2.1: sodium hydroxide

3.1: sodium acetate / 100 °C

With sodium acetate; sodium carbonate; sodium hydroxide;

DOI:10.1016/j.bmc.2013.01.014

Reference yield:

N-(p-aminobenzoyl)glycine diazonium salt (82588-16-7) → 1-[2-(4-{4-[1-(4-fluorophenyl)methylidene]-5-oxo-4,5-dihydro-1,3-oxazol-2-yl}phenyl)-1-diazenyl]-2-naphthyl acetate (1428486-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide

2: sodium acetate / 100 °C

With sodium acetate; sodium hydroxide;

DOI:10.1016/j.bmc.2013.01.014

upstream raw materials:

sodium 2-({4-[2-(2-hydroxy-1-naphthyl)-1-diazenyl]benzoyl}amino)acetate

acetic anhydride

4-fluorobenzaldehyde

N-(p-aminobenzoyl)glycine diazonium salt