N,N-dimethyl-(1R,2R,4R)-2-<(S)-1-hydroxy-2-(phenylmethoxy)ethyl>-4-<(2-methoxyethoxy)methoxy>cyclopentanecarboxamide

Base Information

Chemical Name:N,N-dimethyl-(1R,2R,4R)-2-<(S)-1-hydroxy-2-(phenylmethoxy)ethyl>-4-<(2-methoxyethoxy)methoxy>cyclopentanecarboxamide
CAS No.:135191-47-8
Molecular Formula:C₂₁H₃₃NO₆
Molecular Weight:395.496
Hs Code.:

Synonyms:N,N-dimethyl-(1R,2R,4R)-2-<(S)-1-hydroxy-2-(phenylmethoxy)ethyl>-4-<(2-methoxyethoxy)methoxy>cyclopentanecarboxamide

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Chemical Property of N,N-dimethyl-(1R,2R,4R)-2-<(S)-1-hydroxy-2-(phenylmethoxy)ethyl>-4-<(2-methoxyethoxy)methoxy>cyclopentanecarboxamide

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Technology Process of N,N-dimethyl-(1R,2R,4R)-2-<(S)-1-hydroxy-2-(phenylmethoxy)ethyl>-4-<(2-methoxyethoxy)methoxy>cyclopentanecarboxamide

There total 6 articles about N,N-dimethyl-(1R,2R,4R)-2-<(S)-1-hydroxy-2-(phenylmethoxy)ethyl>-4-<(2-methoxyethoxy)methoxy>cyclopentanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 135191-46-7
N,N-dimethyl-(1S,2R)-β-<(S)-(2-methoxyethoxy)methoxy>-2-<(phenylmethoxy)methyl>oxiranepentanamide

: 135191-47-8
N,N-dimethyl-(1R,2R,4R)-2-<(S)-1-hydroxy-2-(phenylmethoxy)ethyl>-4-<(2-methoxyethoxy)methoxy>cyclopentanecarboxamide

Guidance literature:: With potassium hydride; In tetrahydrofuran; for 13h;

Reference yield:

: 100-44-7
benzyl chloride

: 135191-47-8
N,N-dimethyl-(1R,2R,4R)-2-<(S)-1-hydroxy-2-(phenylmethoxy)ethyl>-4-<(2-methoxyethoxy)methoxy>cyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / NaH / dimethylsulfoxide / 1 h / Ambient temperature

2: 93 percent / O₃, pyridine / CH₂Cl₂; methanol / 0.06 h

3: 0.435 g / KMnO₄, t-butyl alcohol, ph7 phosphate buffer / H₂O / 0.92 h

4: 1.) triethylamine / 1.) THF, -40 deg C, 22 min, 2.) THF, H₂O, 2.5 h

5: 65 percent / KH / tetrahydrofuran / 13 h

With pyridine; potassium permanganate; ph7 phosphate buffer; potassium hydride; sodium hydride; ozone; triethylamine; tert-butyl alcohol; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 135191-45-6
(S)-5-((2R,3R)-3-Benzyloxymethyl-oxiranyl)-4-(2-methoxy-ethoxymethoxy)-pentanal

: 135191-47-8
N,N-dimethyl-(1R,2R,4R)-2-<(S)-1-hydroxy-2-(phenylmethoxy)ethyl>-4-<(2-methoxyethoxy)methoxy>cyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 0.435 g / KMnO₄, t-butyl alcohol, ph7 phosphate buffer / H₂O / 0.92 h

2: 1.) triethylamine / 1.) THF, -40 deg C, 22 min, 2.) THF, H₂O, 2.5 h

3: 65 percent / KH / tetrahydrofuran / 13 h

With potassium permanganate; ph7 phosphate buffer; potassium hydride; triethylamine; tert-butyl alcohol; In tetrahydrofuran; water;