2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl methanesulfonate

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Chemical Name:2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl methanesulfonate
CAS No.:1453212-32-2
Molecular Formula:C₁₉H₂₁F₂N₅O₆S
Molecular Weight:485.468
Hs Code.:

Synonyms:2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl methanesulfonate

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Chemical Property of 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl methanesulfonate

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Technology Process of 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl methanesulfonate

There total 5 articles about 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1453211-61-4
2-chloro-5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidine

: 1453212-32-2
2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; caesium carbonate / 1,4-dioxane / 30 h / 100 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 4 h / 0 °C

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In tetrahydrofuran; 1,4-dioxane; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2022.116657

Reference yield:

: 1453211-60-3
(2,6-difluoro-3,5-dimethoxyphenyl)methyl methanesulfonate

: 1453212-32-2
2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; caesium carbonate / 1,4-dioxane / 30 h / 100 °C / Inert atmosphere

3: triethylamine / tetrahydrofuran / 4 h / 0 °C

With palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 2: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2022.116657

Reference yield:

: 948571-47-9
2-(4-amino-1H-pyrazol-1-yl)ethan-1-ol

: 1453212-32-2
2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; caesium carbonate / 1,4-dioxane / 30 h / 100 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 4 h / 0 °C

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In tetrahydrofuran; 1,4-dioxane; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2022.116657