N-BIS-BOC-4-BROMO-2,6-DICHLOROANILINE

Base Information

• Chemical Name: N-BIS-BOC-4-BROMO-2,6-DICHLOROANILINE
• CAS No.: 915145-00-5
• Molecular Formula: C₁₆H₂₀BrCl₂NO₄
• Molecular Weight: 441.149
• Mol file: 915145-00-5.mol

Synonyms:di-tert-butyl N-(4-bromo-2,6-dichlorophenyl)iminodicarboxylate

Chemical Property of N-BIS-BOC-4-BROMO-2,6-DICHLOROANILINE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-BIS-BOC-4-BROMO-2,6-DICHLOROANILINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-BIS-BOC-4-BROMO-2,6-DICHLOROANILINE

There total 1 articles about N-BIS-BOC-4-BROMO-2,6-DICHLOROANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-bromo-2,6-dichloroaniline (697-88-1) → di-tert-butyl N-(4-bromo-2,6-dichlorophenyl)iminodicarboxylate (915145-00-5)

Guidance literature:

With dmap; In tetrahydrofuran; for 12h; Heating;

DOI:10.1002/ejoc.200600350

Reference yield: 98.0%

di-tert-butyl N-(4-bromo-2,6-dichlorophenyl)iminodicarboxylate (915145-00-5) → tert-butyl (4-bromo-2,6-dichlorophenyl)carbamate (915145-01-6)

Guidance literature:

With potassium carbonate; In methanol; for 12h; Heating;

DOI:10.1002/ejoc.200600350

Reference yield:

di-tert-butyl N-(4-bromo-2,6-dichlorophenyl)iminodicarboxylate (915145-00-5) → 4-(tert-butoxycarboxamido)-3,5-dichlorobenzoic acid

Guidance literature:

Multi-step reaction with 2 steps

1.1: 98 percent / potassium carbonate / methanol / 12 h / Heating

2.1: butyllithium / hexane; tetrahydrofuran / 0.25 h / -75 °C

2.2: 90 percent / hexane; tetrahydrofuran

With n-butyllithium; potassium carbonate; In tetrahydrofuran; methanol; hexane;

DOI:10.1002/ejoc.200600350

upstream raw materials:

di-tert-butyl dicarbonate

4-bromo-2,6-dichloroaniline

Downstream raw materials:

tert-butyl (4-bromo-2,6-dichlorophenyl)carbamate

Refernces