(2S)-N-<(benzyloxy)carbonyl>-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>pyrrolidine

Base Information

Chemical Name:(2S)-N-<(benzyloxy)carbonyl>-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>pyrrolidine
CAS No.:144735-41-1
Molecular Formula:C₂₄H₃₁NO₅
Molecular Weight:413.514
Hs Code.:

Synonyms:(2S)-N-<(benzyloxy)carbonyl>-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>pyrrolidine

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Chemical Property of (2S)-N-<(benzyloxy)carbonyl>-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>pyrrolidine

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Technology Process of (2S)-N-<(benzyloxy)carbonyl>-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>pyrrolidine

There total 9 articles about (2S)-N-<(benzyloxy)carbonyl>-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 153108-85-1
(2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>pyrrolidine

: 144735-41-1
(2S)-N-<(benzyloxy)carbonyl>-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>pyrrolidine

Guidance literature:: With triethylamine; In dichloromethane; for 0.5h; Ambient temperature;

Reference yield:

: 91550-08-2
(S)-2-acetylpyrrolidine-1-carboxylic acid tert-butyl ester

: 144735-41-1
(2S)-N-<(benzyloxy)carbonyl>-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: CH₂Cl₂ / Ambient temperature

2: 1.) BuLi / 1.) hexane, THF, -30 deg C to -20 deg C, 1.5 h, 2.) hexane, THF, -78 deg C, 30 min

3: 68 percent / Hg(ClO₄)2*3H₂O / CHCl₃ / 3 h / Ambient temperature

4: 89 percent / Et₃N / tetrahydrofuran / 2.5 h / Ambient temperature

5: 91 percent / KH / tetrahydrofuran / 2 h / Heating

6: 95 percent / AgNO₃ / ethanol / 1 h / Ambient temperature

7: 79 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

With n-butyllithium; mercury(II) perchlorate; potassium hydride; silver nitrate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform;

Reference yield:

: 120966-83-8
(S)-2-acetylpyrrolidine trifluoroacetate

: 144735-41-1
(2S)-N-<(benzyloxy)carbonyl>-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>pyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) BuLi / 1.) hexane, THF, -30 deg C to -20 deg C, 1.5 h, 2.) hexane, THF, -78 deg C, 30 min

2: 68 percent / Hg(ClO₄)2*3H₂O / CHCl₃ / 3 h / Ambient temperature

3: 89 percent / Et₃N / tetrahydrofuran / 2.5 h / Ambient temperature

4: 91 percent / KH / tetrahydrofuran / 2 h / Heating

5: 95 percent / AgNO₃ / ethanol / 1 h / Ambient temperature

6: 79 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

With n-butyllithium; mercury(II) perchlorate; potassium hydride; silver nitrate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform;