(R)-1-[(4S,5S)-5-((S)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethylamine

Base Information

• Chemical Name: (R)-1-[(4S,5S)-5-((S)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethylamine
• CAS No.: 218271-99-9
• Molecular Formula: C₂₁H₂₈N₂O₂
• Molecular Weight: 340.466
• Mol file: 218271-99-9.mol

Synonyms:(R)-1-[(4S,5S)-5-((S)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethylamine

Chemical Property of (R)-1-[(4S,5S)-5-((S)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-[(4S,5S)-5-((S)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethylamine

There total 8 articles about (R)-1-[(4S,5S)-5-((S)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S,4S,5S)-2,5-bis(N-benzylhydroxylamine)-3,4-O-isopropylidene-1,6-diphenyl-3,4-hexanediol (207561-63-5) → (R)-1-[(4S,5S)-5-((S)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethylamine (218271-99-9)

Guidance literature:

With hydrogen; palladium hydroxide - carbon; In ethanol; acetic acid; for 18h; under 2280 Torr;

DOI:10.1016/S0040-4039(98)00330-X

Reference yield:

1-((4S,5S)-5-{1-[(E)-Hydroxyimino]-2-phenyl-ethyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethanone oxime → (1R,1'R)-1,1'-((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(2-phenylethanamine) (170870-15-2) + (R)-1-[(4S,5S)-5-((S)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethylamine (218271-99-9)

Guidance literature:

With ammonium hydroxide; hydrogen; nickel; In methanol; for 20h; under 1034.3 Torr; Yield given; Yields of byproduct given;

DOI:10.1021/jm980255b

Reference yield:

(2S,3S,4S,5R)-2-N-benzylhydroxylamine-5-tert-butoxycarbonylamine-1,6-diphenyl-3,4-O-isopropylidene-3,4-hexanediol (219586-74-0) → (R)-1-[(4S,5S)-5-((S)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethylamine (218271-99-9)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethanol; acetic acid; for 18h; under 2280 Torr; Ambient temperature;

DOI:10.1021/jo980980u

upstream raw materials:

(3S,4S)-2,5-bis(methoxyimino)-1,6-diphenyl-3,4-O-isopropylidenehexanediol

(2S,3S,4S,5R)-2-N-benzylhydroxylamine-5-tert-butoxycarbonylamine-1,6-diphenyl-3,4-O-isopropylidene-3,4-hexanediol

(2R,3S,4S,5S)-2,5-bis(N-benzylhydroxylamine)-3,4-O-isopropylidene-1,6-diphenyl-3,4-hexanediol

(+)-(4R,5R)-1-(2,2-dimethyl-5-phenylacetyl-[1,3]dioxolan-4-yl)-2-phenylethanone

Downstream raw materials:

(3aS,4R,8S,8aS)-4,8-Dibenzyl-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

(2R,3S,4S,5S)-2,5-diamino-1,6-diphenyl-3,4-hexanediol

(4S,5S,6S,7R)-1,3,4,7-Tetrabenzyl-5,6-dihydroxy-[1,3]diazepan-2-one

(3aS,4S,8R,8aS)-4,5,7,8-Tetrabenzyl-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one