(3aS,4R,8S,8aS)-4,8-Dibenzyl-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Base Information

• Chemical Name: (3aS,4R,8S,8aS)-4,8-Dibenzyl-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one
• CAS No.: 218272-00-5
• Molecular Formula: C₂₂H₂₆N₂O₃
• Molecular Weight: 366.46
• Mol file: 218272-00-5.mol

Synonyms:(3aS,4R,8S,8aS)-4,8-Dibenzyl-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Chemical Property of (3aS,4R,8S,8aS)-4,8-Dibenzyl-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aS,4R,8S,8aS)-4,8-Dibenzyl-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

There total 4 articles about (3aS,4R,8S,8aS)-4,8-Dibenzyl-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1,1'-carbonyldiimidazole (530-62-1) + (R)-1-[(4S,5S)-5-((S)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethylamine (218271-99-9) → (3aS,4R,8S,8aS)-4,8-Dibenzyl-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one (218272-00-5)

Guidance literature:

In various solvent(s); Heating;

DOI:10.1021/jm980255b

Reference yield:

1-((4S,5S)-5-{1-[(E)-Hydroxyimino]-2-phenyl-ethyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethanone oxime → (3aS,4R,8S,8aS)-4,8-Dibenzyl-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one (218272-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, 28 percent aq. NH₄OH / Raney-Ni / methanol / 20 h / 1034.3 Torr

2: 75 percent / various solvent(s) / Heating

With ammonium hydroxide; hydrogen; nickel; In methanol;

DOI:10.1021/jm980255b

Reference yield:

(+)-(4R,5R)-1-(2,2-dimethyl-5-phenylacetyl-[1,3]dioxolan-4-yl)-2-phenylethanone (218271-90-0) → (3aS,4R,8S,8aS)-4,8-Dibenzyl-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one (218272-00-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / ethanol

2: BH₃ / tetrahydrofuran / 2 h / Heating

3: 75 percent / various solvent(s) / Heating

With borane; In tetrahydrofuran; ethanol;

DOI:10.1021/jm980255b

upstream raw materials:

1,1'-carbonyldiimidazole

(R)-1-[(4S,5S)-5-((S)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethylamine

(+)-(4R,5R)-1-(2,2-dimethyl-5-phenylacetyl-[1,3]dioxolan-4-yl)-2-phenylethanone

(3S,4S)-2,5-bis(methoxyimino)-1,6-diphenyl-3,4-O-isopropylidenehexanediol

Downstream raw materials:

(3aS,4S,8R,8aS)-4,5,7,8-Tetrabenzyl-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

(4S,5S,6S,7R)-1,3,4,7-Tetrabenzyl-5,6-dihydroxy-[1,3]diazepan-2-one