11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-10-methanesulfonyl-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one

Base Information

Chemical Name:11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-10-methanesulfonyl-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one
CAS No.:1048041-29-7
Molecular Formula:C₂₉H₂₉ClN₂O₅S
Molecular Weight:553.079
Hs Code.:

Synonyms:11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-10-methanesulfonyl-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one

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Chemical Property of 11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-10-methanesulfonyl-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one

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Technology Process of 11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-10-methanesulfonyl-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one

There total 11 articles about 11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-10-methanesulfonyl-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 81363-76-0
propane-2-sulfonamide

: 1048041-25-3
[11-(4-(benzyloxy)-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepine-10-sulfonyl]acetic acid

: 1048041-29-7
11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-10-methanesulfonyl-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one

: propane-2-sulfonic acid {2-[11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepine-10-sulfonyl]acetyl}amide

Guidance literature:: propane-2-sulfonamide; [11-(4-(benzyloxy)-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepine-10-sulfonyl]acetic acid; With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole; at 20 ℃; for 12h;

With hydrogenchloride; water; at 20 ℃; for 1h;

Reference yield:

: 603-85-0
2-Amino-3-nitrophenol

: 1048041-29-7
11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-10-methanesulfonyl-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one

: propane-2-sulfonic acid {2-[11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepine-10-sulfonyl]acetyl}amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C

2.1: toluene / Heating / reflux

3.1: acetic acid / ethanol / 12 h / Heating / reflux

4.1: potassium tert-butylate / tetrahydrofuran / 0.27 h / 0 °C

4.2: 1.17 h / 0 - 20 °C

5.1: sodium hydride / tetrahydrofuran / 36 h / 0 - 20 °C

6.1: lithium hydroxide / tetrahydrofuran; water / 3 h

6.2: 1 h / 20 °C / pH 1

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole / 12 h / 20 °C

7.2: 1 h / 20 °C

With lithium hydroxide; potassium tert-butylate; hydrogen; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; toluene;

Reference yield:

: 117490-57-0
4-(benzyloxy)-2-chlorobenzaldehyde

: 1048041-29-7
11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-10-methanesulfonyl-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one

: propane-2-sulfonic acid {2-[11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepine-10-sulfonyl]acetyl}amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / ethanol / 12 h / Heating / reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.27 h / 0 °C

2.2: 1.17 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 36 h / 0 - 20 °C

4.1: lithium hydroxide / tetrahydrofuran; water / 3 h

4.2: 1 h / 20 °C / pH 1

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole / 12 h / 20 °C

5.2: 1 h / 20 °C

With lithium hydroxide; potassium tert-butylate; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; water;