1-(3,4-dichlorophenyl)-3-(4-(6,7-dimethoxy-2-methylquinolin-3-yloxy)phenyl)urea

Base Information

• Chemical Name: 1-(3,4-dichlorophenyl)-3-(4-(6,7-dimethoxy-2-methylquinolin-3-yloxy)phenyl)urea
• CAS No.: 1452849-39-6
• Molecular Formula: C₂₅H₂₁Cl₂N₃O₄
• Molecular Weight: 498.365

Synonyms:1-(3,4-dichlorophenyl)-3-(4-(6,7-dimethoxy-2-methylquinolin-3-yloxy)phenyl)urea

Chemical Property of 1-(3,4-dichlorophenyl)-3-(4-(6,7-dimethoxy-2-methylquinolin-3-yloxy)phenyl)urea

Chemical Property:

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Technology Process of 1-(3,4-dichlorophenyl)-3-(4-(6,7-dimethoxy-2-methylquinolin-3-yloxy)phenyl)urea

There total 6 articles about 1-(3,4-dichlorophenyl)-3-(4-(6,7-dimethoxy-2-methylquinolin-3-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-(6,7-dimethoxy-2-methylquinolin-3-yloxy)benzenamine (1452849-33-0) + 3,4-dichlorophenylisocyanate (102-36-3) → 1-(3,4-dichlorophenyl)-3-(4-(6,7-dimethoxy-2-methylquinolin-3-yloxy)phenyl)urea (1452849-39-6)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.5012/bkcs.2013.34.6.1848

Reference yield:

1-(4-nitrophenoxy)propan-2-one (6698-72-2) → 1-(3,4-dichlorophenyl)-3-(4-(6,7-dimethoxy-2-methylquinolin-3-yloxy)phenyl)urea (1452849-39-6)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / ethanol / 24 h / Reflux

2: palladium 10% on activated carbon / methanol / 4 h / 20 °C

3: potassium carbonate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With piperidine; palladium 10% on activated carbon; potassium carbonate; In tetrahydrofuran; methanol; ethanol; 3: |Friedlaender Quinoline Synthesis;

DOI:10.5012/bkcs.2013.34.6.1848

Reference yield:

2-amino-4,5-dimethoxybenzaldehyde (22608-87-3) → 1-(3,4-dichlorophenyl)-3-(4-(6,7-dimethoxy-2-methylquinolin-3-yloxy)phenyl)urea (1452849-39-6)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / ethanol / 24 h / Reflux

2: palladium 10% on activated carbon / methanol / 4 h / 20 °C

3: potassium carbonate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With piperidine; palladium 10% on activated carbon; potassium carbonate; In tetrahydrofuran; methanol; ethanol; 3: |Friedlaender Quinoline Synthesis;

DOI:10.5012/bkcs.2013.34.6.1848

upstream raw materials:

4-(6,7-dimethoxy-2-methylquinolin-3-yloxy)benzenamine

3,4-dichlorophenylisocyanate

2-amino-4,5-dimethoxybenzaldehyde

1-(4-nitrophenoxy)propan-2-one

Downstream raw materials:

1-(3,4-dichlorophenyl)-3-(4-(6,7-dihydroxy-2-methylquinolin-3-yloxy)phenyl)urea

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