benzyl O-benzyl-N-{[(8S,11S,14S)-5,17-bis(benzyloxy)-14-{[(benzyloxy)carbonyl]amino}-11-((2R)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxypropyl)-10,13-dioxo-9,12-diazatricyclo[14.3 .1.1{2.6}]henicosa-1⁽²⁰⁾,2⁽²¹⁾,3,5,16,18-hexaen-8-yl]carbonyl}-L-tyrosinate

Base Information

• Chemical Name: benzyl O-benzyl-N-{[(8S,11S,14S)-5,17-bis(benzyloxy)-14-{[(benzyloxy)carbonyl]amino}-11-((2R)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxypropyl)-10,13-dioxo-9,12-diazatricyclo[14.3 .1.1{2.6}]henicosa-1⁽²⁰⁾,2⁽²¹⁾,3,5,16,18-hexaen-8-yl]carbonyl}-L-tyrosinate
• CAS No.: 868073-51-2
• Molecular Formula: C₇₆H₇₃N₅O₁₃
• Molecular Weight: 1264.44

Synonyms:benzyl O-benzyl-N-{[(8S,11S,14S)-5,17-bis(benzyloxy)-14-{[(benzyloxy)carbonyl]amino}-11-((2R)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxypropyl)-10,13-dioxo-9,12-diazatricyclo[14.3 .1.1{2.6}]henicosa-1⁽²⁰⁾,2⁽²¹⁾,3,5,16,18-hexaen-8-yl]carbonyl}-L-tyrosinate

Chemical Property of benzyl O-benzyl-N-{[(8S,11S,14S)-5,17-bis(benzyloxy)-14-{[(benzyloxy)carbonyl]amino}-11-((2R)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxypropyl)-10,13-dioxo-9,12-diazatricyclo[14.3 .1.1{2.6}]henicosa-1⁽²⁰⁾,2⁽²¹⁾,3,5,16,18-hexaen-8-yl]carbonyl}-L-tyrosinate

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Technology Process of benzyl O-benzyl-N-{[(8S,11S,14S)-5,17-bis(benzyloxy)-14-{[(benzyloxy)carbonyl]amino}-11-((2R)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxypropyl)-10,13-dioxo-9,12-diazatricyclo[14.3 .1.1{2.6}]henicosa-1⁽²⁰⁾,2⁽²¹⁾,3,5,16,18-hexaen-8-yl]carbonyl}-L-tyrosinate

There total 1 articles about benzyl O-benzyl-N-{[(8S,11S,14S)-5,17-bis(benzyloxy)-14-{[(benzyloxy)carbonyl]amino}-11-((2R)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxypropyl)-10,13-dioxo-9,12-diazatricyclo[14.3 .1.1{2.6}]henicosa-1⁽²⁰⁾,2⁽²¹⁾,3,5,16,18-hexaen-8-yl]carbonyl}-L-tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

benzyl (6R,8S,11S,14S)-8-amino-14-[4-(benzyloxy)benzyl]-11-({4,4'-bis(benzyloxy)-3'-[2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorphenoxy)propyl]biphenyl-3-yl}methyl)-6-hydroxy-3,9,12-trioxo-1-phenyl-2-oxa-4,10,13-triazapentadecan-15-oate hydrochloride (868073-50-1) → benzyl O-benzyl-N-{[(8S,11S,14S)-5,17-bis(benzyloxy)-14-{[(benzyloxy)carbonyl]amino}-11-((2R)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxypropyl)-10,13-dioxo-9,12-diazatricyclo[14.3 .1.1{2.6}]henicosa-1(20),2(21),3,5,16,18-hexaen-8-yl]carbonyl}-L-tyrosinate (868073-51-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield: 69.0%

benzyl O-benzyl-N-{[(8S,11S,14S)-5,17-bis(benzyloxy)-14-{[(benzyloxy)carbonyl]amino}-11-((2R)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxypropyl)-10,13-dioxo-9,12-diazatricyclo[14.3 .1.1{2.6}]henicosa-1(20),2(21),3,5,16,18-hexaen-8-yl]carbonyl}-L-tyrosinate (868073-51-2) → N-{[(8S,11S,14S)-14-amino-11-[(2R)-3-amino-2-hydroxypropyl]-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo [14.3.1.1{2,6}]henicosa-1(20),2(21),3,5,16,18-hexaen-8-yl]carbonyl}-L-tyrosine dihydrochloride

Guidance literature:

benzyl O-benzyl-N-{[(8S,11S,14S)-5,17-bis(benzyloxy)-14-{[(benzyloxy)carbonyl]amino}-11-((2R)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxypropyl)-10,13-dioxo-9,12-diazatricyclo[14.3 .1.1{2.6}]henicosa-1⁽²⁰⁾,2⁽²¹⁾,3,5,16,18-hexaen-8-yl]carbonyl}-L-tyrosinate; With hydrogen; palladium 10% on activated carbon; In ethanol; water; acetic acid; at 20 ℃; for 48h;

With hydrogenchloride; In ethanol; water; acetic acid;

upstream raw materials:

benzyl (6R,8S,11S,14S)-8-amino-14-[4-(benzyloxy)benzyl]-11-({4,4'-bis(benzyloxy)-3'-[2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorphenoxy)propyl]biphenyl-3-yl}methyl)-6-hydroxy-3,9,12-trioxo-1-phenyl-2-oxa-4,10,13-triazapentadecan-15-oate hydrochloride

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