2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-(ethoxy-4-oxobutyl)>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

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Chemical Name:2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-(ethoxy-4-oxobutyl)>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester
CAS No.:109522-75-0
Molecular Formula:C₂₂H₃₀F₂N₂O₆
Molecular Weight:456.487
Hs Code.:

Synonyms:2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-(ethoxy-4-oxobutyl)>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

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Chemical Property of 2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-(ethoxy-4-oxobutyl)>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

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Technology Process of 2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-(ethoxy-4-oxobutyl)>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

There total 4 articles about 2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-(ethoxy-4-oxobutyl)>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.2%

: 667-27-6
Ethyl bromodifluoroacetate

: 109522-66-9
*,R^*)>-2-<<<1-Formyl-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

: 109522-75-0
2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-(ethoxy-4-oxobutyl)>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

Guidance literature:: With zinc; In tetrahydrofuran; for 4h; Heating;
DOI:10.1021/ja00191a039

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 109522-75-0
2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-(ethoxy-4-oxobutyl)>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -20 deg C, 15 min; 2.) -40 deg C -> room temp.

2: 100 percent / 1.) oxalyl chloride, DMSO; 2.) diisopropylethylamine / CH₂Cl₂ / 1.) -25 deg C, 1 h; 2.) -40 deg C -> room temp.

3: 39.2 percent / Zn / tetrahydrofuran / 4 h / Heating

With 4-methyl-morpholine; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; zinc; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00191a039

Reference yield:

: 95924-70-2
*,R^*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

: 109522-75-0
2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-(ethoxy-4-oxobutyl)>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 1.) oxalyl chloride, DMSO; 2.) diisopropylethylamine / CH₂Cl₂ / 1.) -25 deg C, 1 h; 2.) -40 deg C -> room temp.

2: 39.2 percent / Zn / tetrahydrofuran / 4 h / Heating

With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00191a039