3-acetyl-6-bromo-1-((4-fluorophenyl)methyl)-4(1H)-quinolinone

Base Information

• Chemical Name: 3-acetyl-6-bromo-1-((4-fluorophenyl)methyl)-4(1H)-quinolinone
• CAS No.: 1187551-48-9
• Molecular Formula: C₁₈H₁₃BrFNO₂
• Molecular Weight: 374.209
• Mol file: 1187551-48-9.mol

Synonyms:3-acetyl-6-bromo-1-((4-fluorophenyl)methyl)-4(1H)-quinolinone

Chemical Property of 3-acetyl-6-bromo-1-((4-fluorophenyl)methyl)-4(1H)-quinolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-acetyl-6-bromo-1-((4-fluorophenyl)methyl)-4(1H)-quinolinone

There total 1 articles about 3-acetyl-6-bromo-1-((4-fluorophenyl)methyl)-4(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-acetyl-6-bromoquinolin-4(1H)-one (1187551-47-8,99867-16-0) + 4-Fluorobenzyl bromide (459-46-1) → 3-acetyl-6-bromo-1-((4-fluorophenyl)methyl)-4(1H)-quinolinone (1187551-48-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

DOI:10.1016/j.bmcl.2009.06.044

Reference yield: 74.0%

3-acetyl-6-bromo-1-((4-fluorophenyl)methyl)-4(1H)-quinolinone (1187551-48-9) + oxalic acid diethyl ester (95-92-1) → ethyl [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl]-4-hydroxy-2-oxo-3-butenoate (1187551-45-6)

Guidance literature:

With hydrogenchloride; sodium ethanolate; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1016/j.bmcl.2009.06.044

Reference yield: 62.0%

3-acetyl-6-bromo-1-((4-fluorophenyl)methyl)-4(1H)-quinolinone (1187551-48-9) + ethyl acrylate (140-88-5,9003-32-1) → (E)-ethyl [3-acetyl-1-(4-fluorophenyl)methyl-4(1H)-quinolinon-6-yl]acrylate (1297310-96-3)

Guidance literature:

With palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 80 ℃; for 48h; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.02.028

upstream raw materials:

3-acetyl-6-bromoquinolin-4(1H)-one

4-Fluorobenzyl bromide

Downstream raw materials:

ethyl [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl]-4-hydroxy-2-oxo-3-butenoate

4-[6-((E)-3-hydroxy-3-oxoprop-1-enyl)-1-(4-fluorophenyl)methyl-4(1H)-quinolinon-3-yl]-2-hydroxy-4-oxo-2-butenoic acid

(E)-ethyl [3-acetyl-1-(4-fluorophenyl)methyl-4(1H)-quinolinon-6-yl]acrylate

4-[6-((E)-3-ethoxy-3-oxoprop-1-enyl)-1-(4-fluorophenyl)methyl-4(1H)-quinolinon-3-yl]-2-hydroxy-4-oxo-2-butenoic acid ethyl ester