3-[2-(methylphenylamino)-4-phenylthiazol-5-yl]-3-oxopropionic acid ethyl ester

Base Information

Chemical Name:3-[2-(methylphenylamino)-4-phenylthiazol-5-yl]-3-oxopropionic acid ethyl ester
CAS No.:1476801-52-1
Molecular Formula:C₂₁H₂₀N₂O₃S
Molecular Weight:380.467
Hs Code.:

Synonyms:3-[2-(methylphenylamino)-4-phenylthiazol-5-yl]-3-oxopropionic acid ethyl ester

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Chemical Property of 3-[2-(methylphenylamino)-4-phenylthiazol-5-yl]-3-oxopropionic acid ethyl ester

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Technology Process of 3-[2-(methylphenylamino)-4-phenylthiazol-5-yl]-3-oxopropionic acid ethyl ester

There total 3 articles about 3-[2-(methylphenylamino)-4-phenylthiazol-5-yl]-3-oxopropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 111753-03-8
1-{2-[N-methyl(phenyl)amino]-4-phenyl-1,3-thiazol-5-yl}ethanone

: 105-58-8,76619-83-5
Diethyl carbonate

: 1476801-52-1
3-[2-(methylphenylamino)-4-phenylthiazol-5-yl]-3-oxopropionic acid ethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 3h; Reflux;
DOI:10.1007/s00044-013-0825-8

Reference yield:

: 1-[4-phenyl-2-(phenylamino)-1,3-thiazol-5-yl]ethanone

: 1476801-52-1
3-[2-(methylphenylamino)-4-phenylthiazol-5-yl]-3-oxopropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 3 h / Reflux

2: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 °C / Reflux

With sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; mineral oil;
DOI:10.1007/s00044-013-0825-8

Reference yield:

: 39536-03-3
N-(phenylcarbamothioyl)benzenecarboximidamide

: 1476801-52-1
3-[2-(methylphenylamino)-4-phenylthiazol-5-yl]-3-oxopropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / methanol / Reflux

2: potassium carbonate / methanol / 3 h / Reflux

3: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 °C / Reflux

With sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; mineral oil;
DOI:10.1007/s00044-013-0825-8