39536-03-3

Upstream product

• 1670-14-0 benzamidine monohydrochloride 
• 103-72-0 phenyl isothiocyanate 
• 618-39-3 benzamidin 
• 6522-91-4 N-phenyl-guanidine hydrochloride 
• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 4023-02-3 1H-pyrazole-1-carboximidamide hydrochloride 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 
• 57297-29-7 cyclopropylcarboxamidine hydrochloride 
• 2392-68-9 3-chlorophenyl-isothiocyanate 
• 621-30-7 3-methylphenyl isothiocyanate 
• 2253-73-8 isopropyl isothiocyanate 
• 55368-42-8 4-bromobenzamidine hydrochloride 
• 14401-51-5 4-chlorobenzamidine hydrochloride 

Downstream Products

• 17467-60-6 phenyl-3-(phenyl)-[1,2,4]thiadiazol-5-amine 
• 726-25-0 1-benzyl-3-phenylthiourea 
• 51384-17-9 5-(methylsulfanyl)-1,3-diphenyl-1,2,4-triazole 
• 2522-25-0 N-(benzo[d]thiazol-2-yl)benzimidamide 
• 307519-25-1 [N-(amino-phenyl-methylene)-N'-phenyl-carbamimidoylsulfanyl]-acetic acid ethyl ester 
• 4123-32-4 phenyl-1-(4-phenyl-2-phenylamino-1,3-thiazol-5-yl)methanone 
• 3346-44-9 2,5-diphenyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 111753-03-8 1-{2-[N-methyl(phenyl)amino]-4-phenyl-1,3-thiazol-5-yl}ethanone 

Relevant academic research and scientific papers

H2O2-Mediated Synthesis of 1,2,4-Thiadiazole Derivatives in Ethanol at Room Temperature

Herein, we report the H2O2-mediated synthesis of 1,2,4-thiadiazole derivatives under metal-free conditions at room temperature with ethanol as the sole solvent. Various substrates could undergo the reaction smoothly, providing the ex

Transition-metal-free visible Light-promoted photoredox oxidative dehydrogenative cyclization:expeditious approach to 1,2,4-thiadiazoles

A novel visible-light-catalyzed oxidative N-S bond formation for the synthesis of 3,5-disubstituted 1,2,4-thiadiazoles has been developed. This protocol features a metal-free approach, green oxidant, room temperature process, broad substrate scope, good functional group tolerance, excellent yields and a one-pot reaction without the isolation of the intermediates.

External oxidant-free electrooxidative intramolecular S-N bond formation for one-pot synthesis for 3,5-disubstituted 1,2,4-thiadiazoles

An electrochemical oxidative reaction protocol for the synthesis of 5-amino and 3,5-diamino substituted 1,2,4-thiadiazole derivatives has been developed under undivided electrolytic conditions. The newly developed one-pot methodology involves the reaction

Electrochemical Oxidative Intramolecular N-S Bond Formation: Synthesis of 3-Substituted 5-Amino-1,2,4-Thiadiazoles

A facile and efficient protocol for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles has been developed through the electro-oxidative intramolecular dehydrogenative N-S bond formation of imidoyl thioureas. Various 1,2,4-thiadiazole derivatives we

Co-Catalyzed Intramolecular S-N Bond Formation in Water for 1,2-Benzisothiazol-3(2H)-ones and 1,2,4-Thiadiazoles Synthesis

An efficient and versatile Co-catalyzed intramolecular S-N bond formation in water to synthesize 1,2-benzisothiazol-3(2H)-one and 1,2,4-thiadiazoles derivatives in good to excellent yields was developed. The transformation showed great tolerance with a broad range of substituents. The mother liquor was able to be recycled 6 times with minor loss in product yield.

Synthesis of 5-Amino and 3,5-Diamino Substituted 1,2,4-Thiadiazoles by I2-Mediated Oxidative N-S Bond Formation

An oxidative N-S bond formation reaction has been established for 1,2,4-thiadiazole synthesis employing molecular iodine as the sole oxidant. The features of the present reaction include no use of transition metals, mild reaction conditions, simple operat

Efficient Synthesis of Polyfunctionalized Pyrimidine Derivatives

A simple and direct procedure was developed for the synthesis of a novel series of polyfunctionalized pyrimidines. They were prepared via reaction of N-(substituted carbamothioyl)benzimidamides (prepared from the reaction of benzimidamide hydrochloride an

Hypervalent Iodine(III) Mediated Synthesis of 3-Substituted 5-Amino-1,2,4-thiadiazoles through Intramolecular Oxidative S-N Bond Formation

An efficient synthesis of 3-substituted-5-arylamino-1,2,4-thiadiazoles through intramolecular oxidative S-N bond formation of imidoyl thioureas by phenyliodine(III) bis(trifluoroacetate) is reported. The protocol features a metal-free approach, broad subs

Copper-catalyzed synthesis of 3-substituted-5-amino-1,2,4-thiadiazoles via intramolecular N-S bond formation

A copper-catalyzed N-S bond formation was utilized to produce 3-substituted-5-amino-1,2,4-thiadiazoles from imidoyl thioureas obtained by reaction of amidine hydrochlorides with isothiocyanates. Moreover, the 1,2,4-thiadiazoles were generated through a on

An efficient one-pot synthesis of 3-substituted-5-amino-1,2,4-thiadiazoles from isothiocyanates and amidines

An efficient one-pot synthesis of 3-substituted-5-amino-1,2,4-thiadiazoles from isothiocyanates and amidines is described.