(E)-2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-acrylic acid

Base Information

• Chemical Name: (E)-2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-acrylic acid
• CAS No.: 914800-36-5
• Molecular Formula: C₁₆H₁₃FO₄S
• Molecular Weight: 320.341
• Mol file: 914800-36-5.mol

Synonyms:(E)-2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-acrylic acid

Chemical Property of (E)-2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-acrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-acrylic acid

There total 1 articles about (E)-2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

para-methanesulfonylbenzaldehyde (5398-77-6) + p-Fluorophenylacetic acid (405-50-5) → (E)-2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-acrylic acid (914800-36-5)

Guidance literature:

With acetic anhydride; triethylamine; at 90 ℃; for 16h;

DOI:10.1016/j.bmc.2006.08.008

Reference yield: 94.0%

(E)-2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-acrylic acid (914800-36-5) + 2-bromoethyl nitrate (38483-29-3) → 2-nitrooxyethyl (E)-2-(4-fluorophenyl)-3-(4-methanesulfonylphenyl)acrylate (1029146-34-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 36h;

DOI:10.1016/j.bmc.2007.12.006

Reference yield: 36.0%

O2-acetoxymethyl 1-[N-(2-methylsulfonyloxyethyl)-N-methylamino]diazen-1-ium-1,2-diolate (742081-73-8) + (E)-2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-acrylic acid (914800-36-5) → O2-acetoxymethyl-1-(N-ethyl-N-methylamino)diazen-1-ium-1,2-diolate (E)-2-(4-fluorophenyl)-3-(4-methanesulfonylphenyl)acrylate (1029146-29-9)

Guidance literature:

(E)-2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-acrylic acid; With sodium carbonate; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 25 ℃; for 19h;

O²-acetoxymethyl 1-[N-(2-methylsulfonyloxyethyl)-N-methylamino]diazen-1-ium-1,2-diolate; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 25 ℃; for 72h; Further stages.;

DOI:10.1016/j.bmc.2007.12.006

upstream raw materials:

para-methanesulfonylbenzaldehyde

p-Fluorophenylacetic acid

Downstream raw materials:

O²-acetoxymethyl-1-(N-ethyl-N-methylamino)diazen-1-ium-1,2-diolate (E)-2-(4-fluorophenyl)-3-(4-methanesulfonylphenyl)acrylate

2-nitrooxyethyl (E)-2-(4-fluorophenyl)-3-(4-methanesulfonylphenyl)acrylate