Galactose-uridine-5'-diphosphate

Base Information

• Chemical Name: Galactose-uridine-5'-diphosphate
• CAS No.: 2956-16-3
• Molecular Formula: C15H24 N2 O17 P2
• Molecular Weight: 566.306
• UNII: O2HY4WY2W1
• DSSTox Substance ID: DTXSID60903962
• Nikkaji Number: J247.696G
• Wikipedia: Uridine_diphosphate_galactose
• Wikidata: Q259015
• Pharos Ligand ID: BGNYHW6JKYQL
• Metabolomics Workbench ID: 37194
• ChEMBL ID: CHEMBL439009
• Mol file: 2956-16-3.mol

Synonyms:Diphosphate Galactose, Uridine;Diphosphogalactose, Uridine;Galactose, UDP;Galactose, Uridine Diphosphate;Pyrophosphogalactose, Uridine;UDP Galactose;UDPGal;Uridine Diphosphate Galactose;Uridine Diphosphogalactose;Uridine Pyrophosphogalactose

Chemical Property of Galactose-uridine-5'-diphosphate

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 1.10±0.50(Predicted)
• Flash Point: °C
• Density: 1.97g/cm³
• Storage Temp.: −20°C
• Solubility.: H2O: 50 mg/mL, clear, colorless
• XLogP3: -6.3
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 9
• Exact Mass: 566.05502130
• Heavy Atom Count: 36
• Complexity: 964

Purity/Quality:

99%, ^*data from raw suppliers

UDP-GALACTOSE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Nucleic Acids and Derivatives
• Canonical SMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OC3C(C(C(C(O3)CO)O)O)O)O)O
• Isomeric SMILES: C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)O[C@@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)O)O)O

Technology Process of Galactose-uridine-5'-diphosphate

There total 20 articles about Galactose-uridine-5'-diphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

D-Galactose (10257-28-0) + UTP (63-39-8) → uridine-5'-diphosphogalactose (133-89-1,2956-16-3,7307-71-3,7349-77-1,16375-64-7,16375-65-8,16414-46-3,17012-87-2,25318-68-7,78391-94-3,99020-05-0,99945-86-5)

Guidance literature:

With galactokinase; pyruvate kinase; inorganic pyrophosphatase; phosphoenolpyruvic acid; galactose-1-phosphate uridylyltransferase; GalU; ATP; uridine-5'-diphosphoglucose; at 30 ℃; for 24h; pH=8; aq. phosphate buffer; Inert atmosphere;

DOI:10.1039/b815549f

Reference yield: 78.0%

UTP (63-39-8) + mannose-1-phosphate (59-56-3,2240-08-6,2255-14-3,2520-52-7,6799-01-5,10456-01-6,14048-34-1,15978-07-1,19993-19-2,20299-62-1,40591-51-3,62057-78-7,77280-79-6,78341-19-2,27251-84-9,63779-58-8,262856-84-8) → Uridine diphosphate mannose (133-89-1,2956-16-3,7307-71-3,7349-77-1,16375-64-7,16375-65-8,16414-46-3,17012-87-2,25318-68-7,78391-94-3,99020-05-0,99945-86-5)

Guidance literature:

With Glucose-1-phosphate thymidylyltransferase from Streptococcus pneumonia serotype 23F; for 48h; Enzymatic reaction;

DOI:10.1039/d0ra05799a

Reference yield: 60.0%

D-Mannose (530-26-7) + UTP (63-39-8) → Uridine diphosphate mannose (133-89-1,2956-16-3,7307-71-3,7349-77-1,16375-64-7,16375-65-8,16414-46-3,17012-87-2,25318-68-7,78391-94-3,99020-05-0,99945-86-5)

Guidance literature:

With recombinant Bifidobacterium infantis ATCC₁₅₆₉₇ N-acetylhexosamine 1-kinase; recombinant Bifidobacterium longum ATCC₅₅₈₁₃ UDP-sugar pyrophosphorylase; recombinant Pasteurella multocida P-1059 inorganic pyrophosphatase; ATP; magnesium chloride; at 37 ℃; for 24h; pH=8; aq. buffer; Enzymatic reaction;

DOI:10.1039/c2cc17577k

upstream raw materials:

2,3,4,6-tetra-O-benzyl-D-galactopyranose

2,3,4,6-Tetra-O-benzyl-D-galactopyranosyl bromide

D-Galactose

UTP

Downstream raw materials:

D-lactal

D-galactopyranose 1-phosphate

cyanidin 3-O-D-galactoside

Refernces

• 1、 Chen, Zonggang,Gu, Guofeng,Jin, Guoxia,Li, Siqiang,Wang, Hong. "Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from: Streptococcus pneumonia serotype 23F". . p. 30110 - 30114. Retrieved 2020/09/07.
• 2、 Muthana, Musleh M.,Qu, Jingyao,Li, Yanhong,Zhang, Lei,Yu, Hai,Ding, Li,Malekan, Hamed,Chen, Xi. "Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP)". supporting information; experimental part. p. 2728 - 2730. Retrieved 2012/04/17.