1-(5-chloro-2-methoxy-4-methylphenylsulphonyl)-5-oxo-pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:1-(5-chloro-2-methoxy-4-methylphenylsulphonyl)-5-oxo-pyrrolidine-2-carboxylic acid
CAS No.:1449569-27-0
Molecular Formula:C₁₃H₁₄ClNO₆S
Molecular Weight:347.776
Hs Code.:

Synonyms:1-(5-chloro-2-methoxy-4-methylphenylsulphonyl)-5-oxo-pyrrolidine-2-carboxylic acid

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Chemical Property of 1-(5-chloro-2-methoxy-4-methylphenylsulphonyl)-5-oxo-pyrrolidine-2-carboxylic acid

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Technology Process of 1-(5-chloro-2-methoxy-4-methylphenylsulphonyl)-5-oxo-pyrrolidine-2-carboxylic acid

There total 3 articles about 1-(5-chloro-2-methoxy-4-methylphenylsulphonyl)-5-oxo-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1449569-26-9
N-(5-chloro-2-methoxy-4-methylphenylsulphonyl)-glutamic acid

: 1449569-27-0
1-(5-chloro-2-methoxy-4-methylphenylsulphonyl)-5-oxo-pyrrolidine-2-carboxylic acid

Guidance literature:: With acetyl chloride; at 5 ℃; for 3h; Reflux;
DOI:10.1248/cpb.c12-00881

Reference yield:

: 13334-71-9
1-chloro-4-methoxy-2-methylbenzene

: 1449569-27-0
1-(5-chloro-2-methoxy-4-methylphenylsulphonyl)-5-oxo-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: chlorosulfonic acid / 1.5 h / 0 - 20 °C

2: sodium hydroxide / 1 h / 70 °C

3: acetyl chloride / 3 h / 5 °C / Reflux

With chlorosulfonic acid; acetyl chloride; sodium hydroxide; 2: |Schotten-Baumann Reaction;
DOI:10.1248/cpb.c12-00881

Reference yield:

: 889939-48-4
5-chloro-2-methoxy-4-methylbenzene-1-sulfonyl chloride

: 1449569-27-0
1-(5-chloro-2-methoxy-4-methylphenylsulphonyl)-5-oxo-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1 h / 70 °C

2: acetyl chloride / 3 h / 5 °C / Reflux

With acetyl chloride; sodium hydroxide; 1: |Schotten-Baumann Reaction;
DOI:10.1248/cpb.c12-00881